dc.creator | Santos, André Luis | |
dc.creator | Derchain, Sophie Françoise | |
dc.creator | Martins, Marcos Roberto | |
dc.creator | Sarian, Luís Otávio | |
dc.creator | Martinez, Edson Zangiacome | |
dc.creator | Syrjänen, Kari Juhani | |
dc.date | 2003-Nov | |
dc.date | 2015-11-27T12:58:45Z | |
dc.date | 2015-11-27T12:58:45Z | |
dc.date.accessioned | 2018-03-29T01:00:19Z | |
dc.date.available | 2018-03-29T01:00:19Z | |
dc.identifier | São Paulo Medical Journal = Revista Paulista De Medicina. v. 121, n. 6, p. 238-43, 2003-Nov. | |
dc.identifier | 1516-3180 | |
dc.identifier | /S1516-31802003000600004 | |
dc.identifier | http://www.ncbi.nlm.nih.gov/pubmed/14989139 | |
dc.identifier | http://repositorio.unicamp.br/jspui/handle/REPOSIP/196132 | |
dc.identifier | 14989139 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1296365 | |
dc.description | Human papillomavirus (HPV) viral load may have an important role in predicting high-grade cervical intraepithelial neoplasia (CIN) in women with cervical smears showing atypical squamous cells or LSIL. To determine whether the assessment of the viral load of high-risk HPV DNA is useful in predicting the detection of high-grade cervical intraepithelial neoplasia (CIN2 and 3) in women referred because of cervical smears showing only atypical squamous cells or LSIL. Cross-sectional. Colposcopy Clinic in a University hospital. A series of 119 women referred because of atypical squamous cells or LSIL between August 2000 and April 2001 were included. All women were subjected to a new cervical smear, HPV testing for the high-risk types using hybrid capture II (HCII), viral load measurement in relative light units (RLU) and colposcopy, with cervical biopsies (n = 97). Cervical lesions were graded using the CIN classification. Cervical biopsies revealed CIN2 or CIN3 in 11% of the cases, equally among women referred because of atypical squamous cells or LSIL. The HCII test was positive in 16% of women with atypical squamous cells and 52% of those with LSIL (OR = 5.8; 95% CI 1.4 to 26.7). There was strong correlation between CIN2 or CIN3 and positivity for HPV DNA when this group was compared with women with only CIN1 or normal cervix (OR = 7.8; 95% CI 1.5 to 53.4). In ROC analysis for HCII in diagnosing CIN2 and CIN3, the area under the ROC curve was 0.784, and the viral load cutoff point of 10.0 RLU/cutcuff presented 77% sensitivity and 73% specificity. Second cytology showing at least atypical squamous cells did not accurately detect CIN2 or CIN3 (OR = 6.4; 95% CI 1.0 to 50.9). The sensitivities of the second cervical smear and HCII were similar, although the specificity of HCII was significantly higher than the second cervical smear. The viral load of high-risk HPV types was significantly associated with the diagnosis of CIN2 or CIN3 in women referred because of atypical squamous cells and LSIL abnormalities in their cervical smear. | |
dc.description | 121 | |
dc.description | 238-43 | |
dc.language | eng | |
dc.relation | São Paulo Medical Journal = Revista Paulista De Medicina | |
dc.relation | Sao Paulo Med J | |
dc.rights | aberto | |
dc.rights | | |
dc.source | PubMed | |
dc.subject | Adolescent | |
dc.subject | Adult | |
dc.subject | Cervical Intraepithelial Neoplasia | |
dc.subject | Cross-sectional Studies | |
dc.subject | Dna, Viral | |
dc.subject | Female | |
dc.subject | Humans | |
dc.subject | Middle Aged | |
dc.subject | Neoplasms, Squamous Cell | |
dc.subject | Papillomaviridae | |
dc.subject | Predictive Value Of Tests | |
dc.subject | Uterine Cervical Neoplasms | |
dc.subject | Vaginal Smears | |
dc.subject | Viral Load | |
dc.title | Human Papillomavirus Viral Load In Predicting High-grade Cin In Women With Cervical Smears Showing Only Atypical Squamous Cells Or Low-grade Squamous Intraepithelial Lesion. | |
dc.type | Artículos de revistas | |