Human Papillomavirus Viral Load In Predicting High-grade Cin In Women With Cervical Smears Showing Only Atypical Squamous Cells Or Low-grade Squamous Intraepithelial Lesion.

dc.creatorSantos, André Luis
dc.creatorDerchain, Sophie Françoise
dc.creatorMartins, Marcos Roberto
dc.creatorSarian, Luís Otávio
dc.creatorMartinez, Edson Zangiacome
dc.creatorSyrjänen, Kari Juhani
dc.date2003-Nov
dc.date2015-11-27T12:58:45Z
dc.date2015-11-27T12:58:45Z
dc.date.accessioned2018-03-29T01:00:19Z
dc.date.available2018-03-29T01:00:19Z
dc.identifierSão Paulo Medical Journal = Revista Paulista De Medicina. v. 121, n. 6, p. 238-43, 2003-Nov.
dc.identifier1516-3180
dc.identifier/S1516-31802003000600004
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/14989139
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/196132
dc.identifier14989139
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1296365
dc.descriptionHuman papillomavirus (HPV) viral load may have an important role in predicting high-grade cervical intraepithelial neoplasia (CIN) in women with cervical smears showing atypical squamous cells or LSIL. To determine whether the assessment of the viral load of high-risk HPV DNA is useful in predicting the detection of high-grade cervical intraepithelial neoplasia (CIN2 and 3) in women referred because of cervical smears showing only atypical squamous cells or LSIL. Cross-sectional. Colposcopy Clinic in a University hospital. A series of 119 women referred because of atypical squamous cells or LSIL between August 2000 and April 2001 were included. All women were subjected to a new cervical smear, HPV testing for the high-risk types using hybrid capture II (HCII), viral load measurement in relative light units (RLU) and colposcopy, with cervical biopsies (n = 97). Cervical lesions were graded using the CIN classification. Cervical biopsies revealed CIN2 or CIN3 in 11% of the cases, equally among women referred because of atypical squamous cells or LSIL. The HCII test was positive in 16% of women with atypical squamous cells and 52% of those with LSIL (OR = 5.8; 95% CI 1.4 to 26.7). There was strong correlation between CIN2 or CIN3 and positivity for HPV DNA when this group was compared with women with only CIN1 or normal cervix (OR = 7.8; 95% CI 1.5 to 53.4). In ROC analysis for HCII in diagnosing CIN2 and CIN3, the area under the ROC curve was 0.784, and the viral load cutoff point of 10.0 RLU/cutcuff presented 77% sensitivity and 73% specificity. Second cytology showing at least atypical squamous cells did not accurately detect CIN2 or CIN3 (OR = 6.4; 95% CI 1.0 to 50.9). The sensitivities of the second cervical smear and HCII were similar, although the specificity of HCII was significantly higher than the second cervical smear. The viral load of high-risk HPV types was significantly associated with the diagnosis of CIN2 or CIN3 in women referred because of atypical squamous cells and LSIL abnormalities in their cervical smear.
dc.description121
dc.description238-43
dc.languageeng
dc.relationSão Paulo Medical Journal = Revista Paulista De Medicina
dc.relationSao Paulo Med J
dc.rightsaberto
dc.rights
dc.sourcePubMed
dc.subjectAdolescent
dc.subjectAdult
dc.subjectCervical Intraepithelial Neoplasia
dc.subjectCross-sectional Studies
dc.subjectDna, Viral
dc.subjectFemale
dc.subjectHumans
dc.subjectMiddle Aged
dc.subjectNeoplasms, Squamous Cell
dc.subjectPapillomaviridae
dc.subjectPredictive Value Of Tests
dc.subjectUterine Cervical Neoplasms
dc.subjectVaginal Smears
dc.subjectViral Load
dc.titleHuman Papillomavirus Viral Load In Predicting High-grade Cin In Women With Cervical Smears Showing Only Atypical Squamous Cells Or Low-grade Squamous Intraepithelial Lesion.
dc.typeArtículos de revistas


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