Microbiological Changes With The Use Of Locally Delivered Doxycycline In The Periodontal Treatment Of Smokers.

dc.creatorMachion, Luciana
dc.creatorAndia, Denise Carleto
dc.creatorSaito, Daniel
dc.creatorKlein, Marlize Inês
dc.creatorGonçalves, Reginaldo Bruno
dc.creatorCasati, Márcio Zafallon
dc.creatorNociti, Francisco H
dc.creatorSallum, Enilson Antonio
dc.date2004-Dec
dc.date2015-11-27T12:58:41Z
dc.date2015-11-27T12:58:41Z
dc.date.accessioned2018-03-29T01:00:10Z
dc.date.available2018-03-29T01:00:10Z
dc.identifierJournal Of Periodontology. v. 75, n. 12, p. 1600-4, 2004-Dec.
dc.identifier0022-3492
dc.identifier10.1902/jop.2004.75.12.1600
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/15732860
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/196096
dc.identifier15732860
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1296329
dc.descriptionThe aim of this study was to evaluate the effect of the association of locally delivered doxycycline 10% and scaling and root planing in the subgingival plaque of smokers. Sixteen smokers with chronic periodontitis and a minimum of four pockets (> or = 5 mm) on anterior teeth that bled on probing were selected. Patients were randomly assigned to one of the following groups: scaling and root planing (SRP) or scaling and root planing followed by local application of doxycycline (SRP-D). Subgingival plaque samples were collected from initially moderate (5 to 6 mm) and deep (> or = 7 mm) pockets at baseline and 3 months. Polymerase chain reaction (PCR) analysis was used to detect the frequency of Actinobacillus actinomycetemcomitans (Aa), Porphyromonas gingivalis (Pg), and Tannerella forsythensis (Tf). No statistically significant difference was found in the reduction of Aa in either the SRP-D or SRP group (P > 0.05). The reduction in Tf, Pg, and Tf + Pg was statistically significant for SRP-D only (P = 0.016, 0.027, and 0.027, respectively). The proportion of sites free of Tf at 3 months was 53% for SRP-D and 9% for SRP (P = 0.02). For Pg, this proportion was 82% and 40%, respectively (P = 0.05). The use of locally delivered doxycycline may promote the elimination of T. forsythensis and P. gingivalis in a greater proportion of sites compared to conventional scaling and root planing in smokers.
dc.description75
dc.description1600-4
dc.languageeng
dc.relationJournal Of Periodontology
dc.relationJ. Periodontol.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAdministration, Topical
dc.subjectAggregatibacter Actinomycetemcomitans
dc.subjectAnti-bacterial Agents
dc.subjectAnti-infective Agents, Local
dc.subjectBacteroides
dc.subjectChronic Disease
dc.subjectColony Count, Microbial
dc.subjectDna, Bacterial
dc.subjectDental Plaque
dc.subjectDental Scaling
dc.subjectDoxycycline
dc.subjectHumans
dc.subjectMicrobial Sensitivity Tests
dc.subjectPeriodontitis
dc.subjectPolymerase Chain Reaction
dc.subjectPorphyromonas Gingivalis
dc.subjectSmoking
dc.titleMicrobiological Changes With The Use Of Locally Delivered Doxycycline In The Periodontal Treatment Of Smokers.
dc.typeArtículos de revistas


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