S-nitrosoglutathione Incorporated In Poly(ethylene Glycol) Matrix: Potential Use For Topical Nitric Oxide Delivery.

dc.creatorSeabra, Amedea Barozzi
dc.creatorde Souza, Gabriela Freitas Pereira
dc.creatorda Rocha, Lilian Lúcia
dc.creatorEberlin, Marcos Nogueira
dc.creatorde Oliveira, Marcelo Ganzarolli
dc.date2004-Nov
dc.date2015-11-27T12:58:36Z
dc.date2015-11-27T12:58:36Z
dc.date.accessioned2018-03-29T00:59:58Z
dc.date.available2018-03-29T00:59:58Z
dc.identifierNitric Oxide : Biology And Chemistry / Official Journal Of The Nitric Oxide Society. v. 11, n. 3, p. 263-72, 2004-Nov.
dc.identifier1089-8603
dc.identifier10.1016/j.niox.2004.09.005
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/15566973
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/196043
dc.identifier15566973
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1296276
dc.descriptionIncorporation of nitric oxide (NO) donors in non-toxic polymeric matrices can be a useful strategy for allowing topical NO delivery. We have incorporated the NO-donor S-nitrosoglutathione (GSNO) into a liquid poly(ethylene glycol) (PEG)/H2O matrix through the S-nitrosation of GSH by a NO/O2 gas mixture. Kinetic measurements of GSNO decomposition associated with NO release were performed at 25, 35, and 45 degrees C in the dark and under irradiation with UV/Vis light, lambda>480 nm and lambda=333 nm. NO release from the liquid matrix to the gas phase was confirmed by mass spectrometry. The PEG/H2O matrix stabilizes GSNO leading to expressive reductions in the initial rates of thermal and photochemical NO release, compared to aqueous GSNO solution. This matrix effect is assigned to diffusional constrains imposed on the escape of the NO and GS radicals formed in the solvent cage. This effect allows the storage of PEG-GSNO formulations for extended periods (more than 65 days at freezer) with negligible decomposition. PEG-GSNO formulation seems therefore to be applicable in topical NO delivery and GSNO displays potential as a percutaneous absorption enhancer. Moreover, the rate of NO release can be locally increased by irradiation with visible light.
dc.description11
dc.description263-72
dc.languageeng
dc.relationNitric Oxide : Biology And Chemistry / Official Journal Of The Nitric Oxide Society
dc.relationNitric Oxide
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAdministration, Topical
dc.subjectDrug Delivery Systems
dc.subjectKinetics
dc.subjectNitric Oxide
dc.subjectNitric Oxide Donors
dc.subjectPhotochemistry
dc.subjectPolyethylene Glycols
dc.subjectS-nitrosoglutathione
dc.subjectSolutions
dc.subjectSpectrum Analysis
dc.subjectTemperature
dc.titleS-nitrosoglutathione Incorporated In Poly(ethylene Glycol) Matrix: Potential Use For Topical Nitric Oxide Delivery.
dc.typeArtículos de revistas


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