Cytotoxicity Of The Phytosterol Diosgenin And Its Derivatives In Rat Cultured Hepatocytes And V79 Fibroblasts.

dc.creatorMelo, Patricia Silva
dc.creatorDe Azevedo, Mariangela Burgos Martins
dc.creatorZullo, Marco Antônio Teixeira
dc.creatorFabrin-Neto, João Batista
dc.creatorHaun, Marcela
dc.date2004-Oct
dc.date2015-11-27T12:58:35Z
dc.date2015-11-27T12:58:35Z
dc.date.accessioned2018-03-29T00:59:56Z
dc.date.available2018-03-29T00:59:56Z
dc.identifierHuman & Experimental Toxicology. v. 23, n. 10, p. 487-93, 2004-Oct.
dc.identifier0960-3271
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/15553174
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/196030
dc.identifier15553174
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1296263
dc.descriptionIn this work, the cytotoxic effects of some spirostane derivatives were examined in cultured hepatocytes and V79 fibroblasts using different viability assays. The derivatives were obtained by modifying the A and B rings of diosgenin. Diosgenin and its derivatives were more toxic in V79 fibroblasts (IC50 40-300 microM) than in hepatocytes (IC50 280-1000 microM). Inhibition of cytochrome P450IIIA in cultured hepatocytes by incubation with 1 mM cimetidine did not alter the toxicity of these compounds in these cells. These observations suggest that other pathways of detoxification may be involved in hepatocytes. In conclusion, the compounds studied merit investigation for their potential pharmacological and industrial applicability.
dc.description23
dc.description487-93
dc.languageeng
dc.relationHuman & Experimental Toxicology
dc.relationHum Exp Toxicol
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectCell Count
dc.subjectCell Line
dc.subjectCell Survival
dc.subjectCimetidine
dc.subjectCricetinae
dc.subjectCricetulus
dc.subjectDna
dc.subjectDiosgenin
dc.subjectDose-response Relationship, Drug
dc.subjectDrug Combinations
dc.subjectFibroblasts
dc.subjectHepatocytes
dc.subjectNeutral Red
dc.subjectRats
dc.subjectTetrazolium Salts
dc.titleCytotoxicity Of The Phytosterol Diosgenin And Its Derivatives In Rat Cultured Hepatocytes And V79 Fibroblasts.
dc.typeArtículos de revistas


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