Postcoital Testing After The Use Of A Bio-adhesive Acid Buffering Gel (acidform) And A 2% Nonoxynol-9 Product.

dc.creatorAmaral, Eliana
dc.creatorPerdigão, Antero
dc.creatorSouza, Maria Helena
dc.creatorMauck, Christine
dc.creatorWaller, Donald
dc.creatorZaneveld, Lourens
dc.creatorFaúndes, Anibal
dc.date2004-Dec
dc.date2015-11-27T12:58:34Z
dc.date2015-11-27T12:58:34Z
dc.date.accessioned2018-03-29T00:59:54Z
dc.date.available2018-03-29T00:59:54Z
dc.identifierContraception. v. 70, n. 6, p. 492-7, 2004-Dec.
dc.identifier0010-7824
dc.identifier10.1016/j.contraception.2004.06.007
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/15541412
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/196023
dc.identifier15541412
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1296256
dc.descriptionACIDFORM is a gel already shown to be safe in vaginal use during six consecutive days through colposcopic observation. A randomized, blinded, crossover study was carried out to compare the spermicidal effect of ACIDFORM to that of a commercial 2% nonoxynol-9 (N-9) product. Twenty sexually active, sterilized women, aged 19-45 years, with regular cycles, normal gynecological exam, no previous sexually transmitted infection (STI) and stable partner willing to undergo four postcoital tests (PCTs) at midcycle during four different menstrual cycles, were enrolled in the study. Known allergy to N-9 or ACIDFORM, oligospermic partner, chronic diseases, use of hormones, previous treatment for STI or presence of STI at screening tests were criteria for exclusion. ACIDFORM or N-9 product administered 0-30 min precoitus or ACIDFORM given 8-10 h precoitus significantly reduced the mean number of progressively motile sperm compared to control cycles (0.19, 0.07, 0.75 vs. 17.94, respectively, p<.05, Wilcoxon test). All treated cycles had five or fewer progressively motile sperm in midcycle cervical mucus, confirming in vivo the spermicidal effect of ACIDFORM previously observed in vitro and in animal models.
dc.description70
dc.description492-7
dc.languageeng
dc.relationContraception
dc.relationContraception
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAdministration, Intravaginal
dc.subjectAdult
dc.subjectBuffers
dc.subjectCoitus
dc.subjectContraceptives, Postcoital
dc.subjectCross-over Studies
dc.subjectDouble-blind Method
dc.subjectFemale
dc.subjectGels
dc.subjectHumans
dc.subjectMale
dc.subjectMenstrual Cycle
dc.subjectMiddle Aged
dc.subjectNonoxynol
dc.subjectSperm Motility
dc.subjectSpermatocidal Agents
dc.subjectTreatment Outcome
dc.subjectVaginal Creams, Foams, And Jellies
dc.subjectVaginal Smears
dc.titlePostcoital Testing After The Use Of A Bio-adhesive Acid Buffering Gel (acidform) And A 2% Nonoxynol-9 Product.
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución