Insights Into The Loss Of Muscle Mass Following B. Jararacussu Venom In Mice.

dc.creatorNeto, Humberto Santo
dc.creatorVomero, Viviane Urbini
dc.creatorMarques, Maria Julia
dc.date2004-Dec
dc.date2015-11-27T12:58:33Z
dc.date2015-11-27T12:58:33Z
dc.date.accessioned2018-03-29T00:59:51Z
dc.date.available2018-03-29T00:59:51Z
dc.identifierToxicon : Official Journal Of The International Society On Toxinology. v. 44, n. 8, p. 847-50, 2004-Dec.
dc.identifier0041-0101
dc.identifier10.1016/j.toxicon.2004.08.007
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/15530966
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/196014
dc.identifier15530966
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1296247
dc.descriptionBothrops jararacussu snake venom produces myonecrosis and nerve degeneration. In this work, we investigated whether nerve lesions or impaired muscle regeneration contributed to the permanent loss of muscle mass, a long-term sequela of envenoming. The right soleus muscle of adult male mice was injected with B. jararacussu venom (80 microg) while the left muscle received only saline (control). The mice were killed after 2 and 3 months and the muscles were removed and processed for examination by transmission electron microscopy and light microscopy. The nerve fibers, Schwann cells and neuromuscular junctions had regenerated in venom-treated muscle. The total number of muscle fibers was significantly lower (p<0.05) than in the control (617+/-48 versus 1235+/-97, respectively; mean+/-SEM, n=10). These results show that the loss of muscle mass was most likely related to a decrease in the ability of the muscle to regenerate rather than to nerve lesions.
dc.description44
dc.description847-50
dc.languageeng
dc.relationToxicon : Official Journal Of The International Society On Toxinology
dc.relationToxicon
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectAxons
dc.subjectBothrops
dc.subjectCrotalid Venoms
dc.subjectMale
dc.subjectMice
dc.subjectMuscle Fibers, Skeletal
dc.subjectMuscle, Skeletal
dc.subjectMuscles
dc.subjectNerve Degeneration
dc.subjectNeuromuscular Junction
dc.subjectRegeneration
dc.titleInsights Into The Loss Of Muscle Mass Following B. Jararacussu Venom In Mice.
dc.typeArtículos de revistas


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