Antiulcer Activity And Subacute Toxicity Of Trans-dehydrocrotonin From Croton Cajucara.

dc.creatorRodríguez, Jaime A
dc.creatorHiruma-Lima, Clélia A
dc.creatorSouza Brito, Alba R M
dc.date2004-Aug
dc.date2015-11-27T12:58:31Z
dc.date2015-11-27T12:58:31Z
dc.date.accessioned2018-03-29T00:59:46Z
dc.date.available2018-03-29T00:59:46Z
dc.identifierHuman & Experimental Toxicology. v. 23, n. 9, p. 455-61, 2004-Aug.
dc.identifier0960-3271
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/15497821
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/195992
dc.identifier15497821
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1296225
dc.descriptionThe antiulcerogenic activity of trans-dehydrocrotonin (DHC), a nor-clerodane diterpene isolated from Croton cajucara Benth. (Euphorbiaceae), and its subacute (35 days) toxicity were studied in mice and rats, respectively. For the antiulcerogenic tests, models of gastric ulcers induced in mice by ethanol/HCl or stress were used. In both models, an oral dose of DHC (100 mg/kg) significantly reduced (P < 0.01) the formation of gastric lesions. DHC was also tested for its ability to scavenge free radicals, but no such action was observed in rat liver mitochondria. To assess the subacute toxicity, rats were treated orally with DHC (25, 50 and 100 mg/kg) for 5 weeks. A significant increase in liver weight was observed in male and female rats at highest doses, whereas a significant reduction in plasma alkaline phosphatase and cholesterol levels and an increase in gamma glutamyl transpeptidase were observed only at the highest dose (100 mg/kg) in female rats. DHC caused histopathological alterations in the liver that included a turbid tumefaction, microvacuolar degeneration and nuclear alterations. Despite the beneficial antiulcerogenic activity of DHC, our results suggest that the long-term use of this compound may induce liver damage.
dc.description23
dc.description455-61
dc.languageeng
dc.relationHuman & Experimental Toxicology
dc.relationHum Exp Toxicol
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAlkaline Phosphatase
dc.subjectAnimals
dc.subjectAnti-ulcer Agents
dc.subjectCholesterol
dc.subjectCroton
dc.subjectDiterpenes, Clerodane
dc.subjectDose-response Relationship, Drug
dc.subjectDrug-induced Liver Injury
dc.subjectEthanol
dc.subjectFemale
dc.subjectFree Radical Scavengers
dc.subjectHydrochloric Acid
dc.subjectLiver
dc.subjectLiver Diseases
dc.subjectMale
dc.subjectMice
dc.subjectMitochondria, Liver
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectStomach Ulcer
dc.subjectThiobarbituric Acid Reactive Substances
dc.subjectWeight Gain
dc.subjectGamma-glutamyltransferase
dc.titleAntiulcer Activity And Subacute Toxicity Of Trans-dehydrocrotonin From Croton Cajucara.
dc.typeArtículos de revistas


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