Protective Effect Of Bovine Milk Whey Protein Concentrate On The Ulcerative Lesions Caused By Subcutaneous Administration Of Indomethacin.

dc.creatorRosaneli, C F
dc.creatorBighetti, A E
dc.creatorAntônio, M A
dc.creatorCarvalho, J E
dc.creatorSgarbieri, V C
dc.date2004
dc.date2015-11-27T12:58:27Z
dc.date2015-11-27T12:58:27Z
dc.date.accessioned2018-03-29T00:59:38Z
dc.date.available2018-03-29T00:59:38Z
dc.identifierJournal Of Medicinal Food. v. 7, n. 3, p. 309-14, 2004.
dc.identifier1096-620X
dc.identifier10.1089/1096620041938722
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/15383224
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/195956
dc.identifier15383224
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1296189
dc.descriptionThe protective effect of a whey protein concentrate (WPC) was studied in three models of stomach ulcerative lesions induction: subcutaneous injection of indomethacin, and stress induced by either intraperitoneal injection of reserpine, or immobilization and holding in the cold (4 degrees C, 2 hours). Adult Wistar rats (300-400 g) were used for acute (single-dose), repetitive, or subchronic (10 days) administration of WPC prior to treatment with the ulcerogenic factors. The best protection was achieved in the indomethacin model for repetitive and subchronic experiments, reaching 50.1% and 44%, respectively, inhibition of the ulcerative lesions, which was significant at 1% probability (P <.01). For the immobilization and cold model, maximum inhibition by WPC was 22.1%, and that for the reserpine model was 23.8%. In both models the inhibition was not significant (P >.05) compared with saline (negative control).
dc.description7
dc.description309-14
dc.languageeng
dc.relationJournal Of Medicinal Food
dc.relationJ Med Food
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectAnti-inflammatory Agents, Non-steroidal
dc.subjectAnti-ulcer Agents
dc.subjectCattle
dc.subjectCimetidine
dc.subjectDisease Models, Animal
dc.subjectGastric Mucosa
dc.subjectImmobilization
dc.subjectIndomethacin
dc.subjectInjections, Intraperitoneal
dc.subjectInjections, Subcutaneous
dc.subjectMale
dc.subjectMilk
dc.subjectMilk Proteins
dc.subjectRandom Allocation
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectReserpine
dc.subjectStomach Ulcer
dc.titleProtective Effect Of Bovine Milk Whey Protein Concentrate On The Ulcerative Lesions Caused By Subcutaneous Administration Of Indomethacin.
dc.typeArtículos de revistas


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