Gene Phylogenies And Protein-protein Interactions: Possible Artifacts Resulting From Shared Protein Interaction Partners.

dc.creatorCampos, Paulo R A
dc.creatorde Oliveira, Viviane M
dc.creatorWagner, Günter P
dc.creatorStadler, Peter F
dc.date2004-Nov
dc.date2015-11-27T12:58:27Z
dc.date2015-11-27T12:58:27Z
dc.date.accessioned2018-03-29T00:59:37Z
dc.date.available2018-03-29T00:59:37Z
dc.identifierJournal Of Theoretical Biology. v. 231, n. 2, p. 197-202, 2004-Nov.
dc.identifier0022-5193
dc.identifier10.1016/j.jtbi.2004.06.014
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/15380384
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/195952
dc.identifier15380384
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1296185
dc.descriptionThe study of gene families critically depends on the correct reconstruction of gene genealogies, as for instance in the case of transcription factor genes like Hox genes and Dlx gene families. Proteins belonging to the same family are likely to share some of the same protein interaction partners and may thus face a similar selective environment. This common selective environment can induce co-evolutionary pressures and thus can give rise to correlated rates and patterns of evolution among members of a gene family. In this study, we simulate the evolution of a family of sequences which share a set of interaction partners. Depending on the amount of sequence dedicated to protein-protein interaction and the relative rate parameters of sequence evolution three outcomes are possible: if the fraction of the sequence dedicated to interaction with common co-factors is low and the time since divergence is small, the trees based on sequence information tend to be correct. If the time since gene duplication is long two possible outcomes are observed in our simulations. If the rate of evolution of the interaction partner is small compared to the rate of evolution of the focal protein family, the reconstructed trees tend towards star phylogenies. As the rate of evolution of the interaction partner approaches that of the focal protein family the reconstructed phylogenies tend to be incorrectly resolved. We conclude that the genealogies of gene families can be hard to estimate, in particular if the proteins interact with a conserved set of binding partners, as is likely the case for transcription factors.
dc.description231
dc.description197-202
dc.languageeng
dc.relationJournal Of Theoretical Biology
dc.relationJ. Theor. Biol.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectComputer Simulation
dc.subjectGene Expression Regulation
dc.subjectModels, Genetic
dc.subjectPhylogeny
dc.subjectProtein Interaction Mapping
dc.titleGene Phylogenies And Protein-protein Interactions: Possible Artifacts Resulting From Shared Protein Interaction Partners.
dc.typeArtículos de revistas


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