Esophageal Atresia And Other Visceral Anomalies In A Modified Adriamycin Rat Model And Their Correlations With Amniotic Fluid Volume Variations.

dc.creatorFrança, Willy M G
dc.creatorGonçalves, Anderson
dc.creatorMoraes, Suzana G
dc.creatorPereira, Luis A V
dc.creatorSbragia, Lourenço
dc.date2004-Aug
dc.date2015-11-27T12:58:25Z
dc.date2015-11-27T12:58:25Z
dc.date.accessioned2018-03-29T00:59:33Z
dc.date.available2018-03-29T00:59:33Z
dc.identifierPediatric Surgery International. v. 20, n. 8, p. 602-8, 2004-Aug.
dc.identifier0179-0358
dc.identifier10.1007/s00383-004-1240-5
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/15338172
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/195935
dc.identifier15338172
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1296168
dc.descriptionThe Adriamycin rat model (ARM) has been used to produce visceral malformations in fetuses to explain the mechanisms of foregut division. The models vary in the dosage of Adriamycin (ADR) and in the number of applications. Our study of a modified ARM using 2.2 mg/kg of ADR for 2 days only, intraperitoneally in pregnant rats, is presented. A total of 81 fetuses were obtained with this model from the ADR group, 74 (91%) alive. Uretero-hydronephrosis (UHN) was observed in 70 fetuses (95%), esophageal atresia (EA) in 68 (92%), duodenal atresia (DA) in 68 (92%), bladder hypoplasia (BH) in 67 (90%), plus other malformations. In evaluating amniotic fluid (AF) volume of the fetuses with EA with tracheo-esophageal fistula (TEF) (group I) and EA without TEF (group II), both associated with bilateral UHN when compared with the control group (group III), groups I and II showed higher AF volume in groups I and II than the control group (group III) did ( p=0.0001). In conclusion, ARM was adequate to produce EA and other visceral malformations. The use of ADR in a higher dosage for a shorter period of time produced better results than those presented in previous literature. The increase of AF volume obtained in fetuses presenting EA plus bilateral UHN strongly suggests, despite ureteral dilatation (urinary obstruction), that a malformed communication may exist between the urinary system and the amniotic cavity, permitting the existence of polyhydramnios that is due to digestive obstruction such as EA and DA.
dc.description20
dc.description602-8
dc.languageeng
dc.relationPediatric Surgery International
dc.relationPediatr. Surg. Int.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAbnormalities, Drug-induced
dc.subjectAmniotic Fluid
dc.subjectAnimals
dc.subjectDigestive System Abnormalities
dc.subjectDisease Models, Animal
dc.subjectDose-response Relationship, Drug
dc.subjectDoxorubicin
dc.subjectEsophageal Atresia
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectPregnancy
dc.subjectRats
dc.subjectRats, Sprague-dawley
dc.subjectTeratogens
dc.subjectUrogenital Abnormalities
dc.titleEsophageal Atresia And Other Visceral Anomalies In A Modified Adriamycin Rat Model And Their Correlations With Amniotic Fluid Volume Variations.
dc.typeArtículos de revistas


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