Cytotoxicity Of Tamoxifen In Normal And Tumoral Cell Lines And Its Ability To Induce Cellular Transformation In Vitro.

dc.creatorPetinari, Leandro
dc.creatorKohn, Luciana Konecny
dc.creatorde Carvalho, João Ernesto
dc.creatorGenari, Selma Candelária
dc.date2004
dc.date2015-11-27T12:58:18Z
dc.date2015-11-27T12:58:18Z
dc.date.accessioned2018-03-29T00:59:19Z
dc.date.available2018-03-29T00:59:19Z
dc.identifierCell Biology International. v. 28, n. 7, p. 531-9, 2004.
dc.identifier1065-6995
dc.identifier10.1016/j.cellbi.2004.04.008
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/15261161
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/195873
dc.identifier15261161
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1296106
dc.descriptionTamoxifen (TAM) is a non-steroidal anti-estrogen used to treat patients with estrogen receptor-positive breast cancer and as a chemopreventive agent against breast cancer in high risk pre- and post-menopausal women. However, recent studies have shown that tamoxifen causes endometrial and hepatic cancer. In this study, we examined the effects of tamoxifen (5, 10, 25 and 50 microM) on the growth and proliferation of nine tumoral cell lines (UACC62, MCF-7, NCI-460, K-562, OVCAR-03, PC-03, HT-29, 786-0, NCI-ADR) and non-tumoral cell lines (3T3, V79, MDCK, VERO). Chinese hamster lung fibroblasts (V79) were the most sensitive lineage to tamoxifen, with 21.6% of the cells showing apoptosis at 50 microM TAM. Microscopic analysis showed that, the cellular transformation caused by TAM in V79 cells was similar to that seen with 7,12-dimethylbenz(a)anthracene, thus indicating the carcinogenicity of TAM.
dc.description28
dc.description531-9
dc.languageeng
dc.relationCell Biology International
dc.relationCell Biol. Int.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectAntineoplastic Agents, Hormonal
dc.subjectApoptosis
dc.subjectCell Line, Tumor
dc.subjectCell Proliferation
dc.subjectCell Transformation, Neoplastic
dc.subjectCricetinae
dc.subjectEstrogen Antagonists
dc.subjectFemale
dc.subjectHumans
dc.subjectTamoxifen
dc.titleCytotoxicity Of Tamoxifen In Normal And Tumoral Cell Lines And Its Ability To Induce Cellular Transformation In Vitro.
dc.typeArtículos de revistas


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