Sensitivity To Beta-adrenoceptor Agonists Of Adipocytes From Rats Treated With An Aqueous Extract Of Croton Cajucara Benth.

dc.creatorGrassi-Kassisse, Dora Maria
dc.creatorWolf-Nunes, Valéria
dc.creatorMiotto, Alexandre Marcucci
dc.creatorFarias-Silva, Elisângela
dc.creatorSouza Brito, Alba Regina Monteiro
dc.creatorNunes, Domingos Savio
dc.creatorSpadari-Bratfisch, Regina Célia
dc.date2003-Feb
dc.date2015-11-27T12:52:44Z
dc.date2015-11-27T12:52:44Z
dc.date.accessioned2018-03-29T00:58:37Z
dc.date.available2018-03-29T00:58:37Z
dc.identifierThe Journal Of Pharmacy And Pharmacology. v. 55, n. 2, p. 253-7, 2003-Feb.
dc.identifier0022-3573
dc.identifier10.1211/002235702595
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/12631418
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/195692
dc.identifier12631418
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1295925
dc.descriptionAqueous extracts of Croton cajucara bark are used in folk medicine to treat hepatic and gastrointestinal disorders and as a coadjuvant in weight-loss programs. We examined the effect of treating rats for 15 days with a 5% aqueous extract of C. cajucara on body weight and food intake. The epididymal adipose pads were removed and the lipolytic responses of isolated adipocytes to isoprenaline, noradrenaline (norepinephrine), BRL37344 and adrenaline (epinephrine) were analysed in the absence or presence of metoprolol or ICI118,551. Treated rats had a significantly lower weight gain than control rats, with no difference in food and liquid intake, epididymal fat-pad weight or basal glycerol release. The sensitivity of the lipolytic response to isoprenaline and adrenaline was significantly higher in adipocytes from treated rats. The sensitivity to noradrenaline or BRL37344 was unaltered. Metoprolol shifted the dose-response curves to noradrenaline to the right in adipocytes from control and treated rats; the dose-response curve to isoprenaline in adipocytes from control rats was also shifted to the right. In adipocytes from treated rats, the dose-response curve to isoprenaline was unaltered by metoprolol but was shifted to the right by ICI118,551, a beta(2)-adrenoceptor antagonist. We conclude that in adipocytes from treated rats there is an increase in the lipolytic response to non-selective agonists (isoprenaline and adrenaline) mediated by beta(2)-adrenoceptors, with no alteration in the responses mediated by beta(1)-adrenoceptors (noradrenaline) or beta(3)-adrenoceptors (BRL37344). This effect could increase the role of adrenaline as an endogenous stimulator of lipolysis.
dc.description55
dc.description253-7
dc.languageeng
dc.relationThe Journal Of Pharmacy And Pharmacology
dc.relationJ. Pharm. Pharmacol.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAdipocytes
dc.subjectAdrenergic Beta-agonists
dc.subjectAnimals
dc.subjectBody Weight
dc.subjectCroton
dc.subjectEating
dc.subjectMale
dc.subjectPlant Preparations
dc.subjectRats
dc.subjectRats, Wistar
dc.titleSensitivity To Beta-adrenoceptor Agonists Of Adipocytes From Rats Treated With An Aqueous Extract Of Croton Cajucara Benth.
dc.typeArtículos de revistas


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