Evidence Of The Effect Of Dipyrone On The Central Nervous System As A Determinant Of Delayed Gastric Emptying Observed In Rats After Its Administration.

dc.creatorCollares, E F
dc.creatorVinagre, A M
dc.date2003-Oct
dc.date2015-11-27T12:52:27Z
dc.date2015-11-27T12:52:27Z
dc.date.accessioned2018-03-29T00:58:02Z
dc.date.available2018-03-29T00:58:02Z
dc.identifierBrazilian Journal Of Medical And Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas / Sociedade Brasileira De Biofísica ... [et Al.]. v. 36, n. 10, p. 1375-82, 2003-Oct.
dc.identifier0100-879X
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/14502370
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/195533
dc.identifier14502370
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1295766
dc.descriptionDipyrone administered intravenously (iv) delays gastric emptying (GE) in rats. The objectives of the present study were to assess: 1) the effect of the dose of dipyrone and time after its iv administration on GE in rats, 2) the effect of subdiaphragmatic vagotomy (VgX) and bilateral electrolytic lesion of the paraventricular nucleus (PVNX) on the delayed GE induced by the drug, and 3) the intracerebroventricular (icv) action of dipyrone and of one of its metabolites, 4-aminoantipyrine on GE. Male Wistar rats received saline labeled with phenol red intragastrically as a test meal. GE was indirectly assessed by the determination of percent gastric retention (GR) of the test meal 10 min after administration by gavage. Dipyrone delays GE in a dose- and time-dependent manner. Thirty minutes after the iv administration of 80 mg/kg dipyrone, the animals showed significantly higher GR (mean = 62.6%) compared to those receiving vehicle (31.5%). VgX and PVNX significantly reduced the iv effect of 80 mg/kg dipyrone (mean %GR: VgX = 28.3 vs Sham = 55.5 and PVNX = 34.5 vs Sham = 52.2). Icv administration of 4 mol dipyrone caused a significant increase in GR (54.1%) of the test meal 10 min later, whereas administration of 4 mol 4-aminoantipyrine had no effect (34.4%). Although the dipyrone dose administered icv was 16 times lower than that applied iv, for the same time of action (10 min), the GR of animals that received the drug icv (54.1%) or iv (54.5%) did not differ significantly. In conclusion, the present results suggest that the effect of dipyrone in delaying GE is due to the action of the drug on the central nervous system, with the participation of the PVN and of the vagus nerve.
dc.description36
dc.description1375-82
dc.languageeng
dc.relationBrazilian Journal Of Medical And Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas / Sociedade Brasileira De Biofísica ... [et Al.]
dc.relationBraz. J. Med. Biol. Res.
dc.rightsaberto
dc.rights
dc.sourcePubMed
dc.subjectAmpyrone
dc.subjectAnalysis Of Variance
dc.subjectAnimals
dc.subjectAnti-inflammatory Agents, Non-steroidal
dc.subjectCentral Nervous System
dc.subjectDipyrone
dc.subjectDose-response Relationship, Drug
dc.subjectGastric Emptying
dc.subjectMale
dc.subjectParaventricular Hypothalamic Nucleus
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectTime Factors
dc.subjectVagotomy
dc.subjectVagus Nerve
dc.titleEvidence Of The Effect Of Dipyrone On The Central Nervous System As A Determinant Of Delayed Gastric Emptying Observed In Rats After Its Administration.
dc.typeArtículos de revistas


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