Expression Of P53, C-erbb-2, Ki-67, And Cd34 In Granulosa Cell Tumor Of The Ovary.

dc.creatorKusamura, S
dc.creatorDerchain, S
dc.creatorAlvarenga, M
dc.creatorGomes, C P
dc.creatorSyrjänen, K J
dc.creatorAndrade, L A L A
dc.date
dc.date2015-11-27T12:52:21Z
dc.date2015-11-27T12:52:21Z
dc.date.accessioned2018-03-29T00:57:49Z
dc.date.available2018-03-29T00:57:49Z
dc.identifierInternational Journal Of Gynecological Cancer : Official Journal Of The International Gynecological Cancer Society. v. 13, n. 4, p. 450-7
dc.identifier1048-891X
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/12911721
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/195480
dc.identifier12911721
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1295713
dc.descriptionThe purpose of this study is to investigate the expression of p53, c-erbB-2, Ki-67, and angiogenic activity and their correlation with the clinicopathologic characteristics in a series of granulosa cell tumors of the ovary (GCTO). Eighteen GCTO cases assisted at the Department of Obstetrics and Gynecology, School of Medical Science, UNICAMP, after diagnostic confirmation by three pathologists, were submitted to immunohistochemistry for assessment of p53, c-erbB-2, Ki-67, and CD34 expressions. The mean tumor size was 13 cm (range: 4-30 cm). Six (33%) cases presented with extraovarian disease. Thirteen (72%) cases presented some solid diffuse or sarcomatoid pattern and six (33%) moderate or strong atypia. Fourteen cases presented </=2 mitoses/10 HPF. Thirteen cases were focally positive for Ki-67. The mean Ki-67 proliferative index was 1.0%. One case presented positive expression for mutant p53 but all cases were negative for c-erbB-2 expression. The mean microvascular density was 28.9/mm2 (range: 0-50). No significant correlations could be established between the biologic markers and clinicopathologic variables. GCTO showed a markedly low rate of immunohistochemical staining for p53 or c-erbB-2 overexpression/amplification, as well as low proliferative and angiogenic activities. Further studies are urgently needed to elaborate the factors responsible for the highly unpredictable clinical course of GCTO.
dc.description13
dc.description450-7
dc.languageeng
dc.relationInternational Journal Of Gynecological Cancer : Official Journal Of The International Gynecological Cancer Society
dc.relationInt. J. Gynecol. Cancer
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 And Over
dc.subjectAntigens, Cd34
dc.subjectBiopsy, Needle
dc.subjectDisease-free Survival
dc.subjectFemale
dc.subjectGenes, P53
dc.subjectGranulosa Cell Tumor
dc.subjectHumans
dc.subjectImmunohistochemistry
dc.subjectKi-67 Antigen
dc.subjectMiddle Aged
dc.subjectOvarian Neoplasms
dc.subjectPrognosis
dc.subjectReceptor, Erbb-2
dc.subjectRisk Assessment
dc.subjectSampling Studies
dc.subjectSensitivity And Specificity
dc.subjectSurvival Analysis
dc.subjectTumor Markers, Biological
dc.titleExpression Of P53, C-erbb-2, Ki-67, And Cd34 In Granulosa Cell Tumor Of The Ovary.
dc.typeArtículos de revistas


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