Outcome Of Surgical Treatment In Familial Mesial Temporal Lobe Epilepsy.

dc.creatorKobayashi, Eliane
dc.creatorD'Agostino, Maria Daniela
dc.creatorLopes-Cendes, Iscia
dc.creatorAndermann, Eva
dc.creatorDubeau, François
dc.creatorGuerreiro, Carlos A M
dc.creatorSchenka, André A
dc.creatorQueiroz, Luciano S
dc.creatorOlivier, André
dc.creatorCendes, Fernando
dc.creatorAndermann, Frederick
dc.date2003-Aug
dc.date2015-11-27T12:52:19Z
dc.date2015-11-27T12:52:19Z
dc.date.accessioned2018-03-29T00:57:46Z
dc.date.available2018-03-29T00:57:46Z
dc.identifierEpilepsia. v. 44, n. 8, p. 1080-4, 2003-Aug.
dc.identifier0013-9580
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/12887440
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/195470
dc.identifier12887440
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1295703
dc.descriptionTo describe postoperative outcome in patients with familial mesial temporal lobe epilepsy (FMTLE). We studied FMTLE patients who underwent surgical treatment for refractory seizures. FMTLE was defined when at least two individuals in a family had a clinical EEG diagnosis of MTLE. Preoperative investigation included magnetic resonance imaging (MRI), interictal/ictal EEGs, and neuropsychological evaluation. We used Engel's classification for postoperative outcome. To date, 20 FMTLE patients have been operated on, with 1.6 to 9.8 years of follow-up (mean, 5.5 years). Hippocampal atrophy (HA) and other signs of mesial temporal sclerosis (MTS) were present in 18 patients (15 unilateral). Seizures were recorded in 19 patients. Seventeen (85%) patients are in class I. Two patients had normal hippocampal volumes (HcV): one (5%) is in class II and the other (5%) in class IV (extratemporal seizures developed after surgery). One (5%) patient had bilateral HA and is in class III. Qualitative histopathology showed MTS with different degrees of severity. Refractory FMTLE patients have good surgical outcome when unilateral or clearly asymmetric HA is identified. Preoperative investigation should be the same as that in patients with sporadic refractory MTLE.
dc.description44
dc.description1080-4
dc.languageeng
dc.relationEpilepsia
dc.relationEpilepsia
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAdult
dc.subjectAmygdala
dc.subjectAnterior Temporal Lobectomy
dc.subjectAtrophy
dc.subjectDominance, Cerebral
dc.subjectElectroencephalography
dc.subjectEpilepsy, Temporal Lobe
dc.subjectFemale
dc.subjectFollow-up Studies
dc.subjectHippocampus
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectTemporal Lobe
dc.subjectTreatment Outcome
dc.titleOutcome Of Surgical Treatment In Familial Mesial Temporal Lobe Epilepsy.
dc.typeArtículos de revistas


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