Cerebellar Volume And Long-term Use Of Phenytoin.

dc.creatorDe Marcos, Felipe Antonio
dc.creatorGhizoni, Enrico
dc.creatorKobayashi, Elaine
dc.creatorLi, Li Min
dc.creatorCendes, Fernano
dc.date2003-Jul
dc.date2015-11-27T12:52:12Z
dc.date2015-11-27T12:52:12Z
dc.date.accessioned2018-03-29T00:57:33Z
dc.date.available2018-03-29T00:57:33Z
dc.identifierSeizure. v. 12, n. 5, p. 312-5, 2003-Jul.
dc.identifier1059-1311
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/12810345
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/195416
dc.identifier12810345
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1295649
dc.descriptionTo perform MRI cerebellum volumetry in patients exposed to phenytoin and to identify factors associated with cerebellar atrophy (CA). From 100 consecutive epilepsy patients we selected those with phenytoin use for more than 2 months and with MRI scan available for volumetric studies. We obtained cerebellar volumes corrected for total intracranial volume. Volumes below 2 standard deviations from the mean of control group were considered abnormal. We studied 56 patients (33 women). Mean age was 33.6 years and mean duration of epilepsy was 17.6 years. Mean daily dose of phenytoin was 301 mg. CA was detected in 20 (35.7%) patients. CA was not associated with frequent generalised seizures. CA correlated with duration of epilepsy (r=-0.34; P=0.01) and years of treatment with phenytoin (r=-0.48; P=0.001), but not with age and mean daily dosage of phenytoin (P>0.05). However, a multiple correlation analysis as well as a backward stepwise multiple regression analysis including all variables showed that only duration of treatment was significantly associated with CA (P=0.001). CA is frequently associated with long-term use of phenytoin. Although duration of epilepsy may have an influence in the CA, this is clearly less important than the time of exposure to phenytoin.
dc.description12
dc.description312-5
dc.languageeng
dc.relationSeizure
dc.relationSeizure
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectAnticonvulsants
dc.subjectCerebellum
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectDose-response Relationship, Drug
dc.subjectEpilepsies, Partial
dc.subjectEpilepsy
dc.subjectEpilepsy, Generalized
dc.subjectEpilepsy, Temporal Lobe
dc.subjectEpilepsy, Tonic-clonic
dc.subjectFemale
dc.subjectHumans
dc.subjectImage Processing, Computer-assisted
dc.subjectLong-term Care
dc.subjectMagnetic Resonance Imaging
dc.subjectMale
dc.subjectMathematical Computing
dc.subjectMiddle Aged
dc.subjectPhenytoin
dc.subjectReference Values
dc.subjectRegression Analysis
dc.subjectRisk Factors
dc.titleCerebellar Volume And Long-term Use Of Phenytoin.
dc.typeArtículos de revistas


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