Thermal And Photochemical Nitric Oxide Release From S-nitrosothiols Incorporated In Pluronic F127 Gel: Potential Uses For Local And Controlled Nitric Oxide Release.

dc.creatorShishido, Sílvia Mika
dc.creatorSeabra, Amedea Barozzi
dc.creatorLoh, Watson
dc.creatorGanzarolli de Oliveira, Marcelo
dc.date2003-Sep
dc.date2015-11-27T12:52:12Z
dc.date2015-11-27T12:52:12Z
dc.date.accessioned2018-03-29T00:57:33Z
dc.date.available2018-03-29T00:57:33Z
dc.identifierBiomaterials. v. 24, n. 20, p. 3543-53, 2003-Sep.
dc.identifier0142-9612
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/12809783
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/195415
dc.identifier12809783
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1295648
dc.descriptionThe local delivery of nitric oxide (nitrogen monoxide, NO) by thermal or photochemical means to target cells or organs has a great potential in several biomedical applications, especially if the NO donors are incorporated into non-toxic viscous matrices. In this work, we have shown that the NO donors S-nitrosoglutathione (GSNO) and S-nitroso-N-acetylcysteine (SNAC) can be incorporated into F127 hydrogels, from where NO can be released thermally or photochemically (with lambda(irr)>480nm). High sensitivity differential scanning calorimetry (HSDSC) and a new spectrophotometric method, were used to characterize the micellization and the reversal thermal gelation processes of the F127 hydrogels containing NO donors, and to modulate the gelation temperatures to the range 29-32 degrees C. Spectral monitoring of the S-NO bond cleavage showed that the initial rates of thermal and photochemical NO release (ranging from 2 to 45 micromoll(-1)min(-1)) are decreased in the hydrogel matrices, relative to those obtained in aqueous solutions. This stabilization effect was assigned to a cage recombination mechanism and offers an additional advantage for the storage and handling of S-nitrosothiols. These results indicate that F127 hydrogels might be used for the thermal and photochemical delivery of NO from S-nitrosothiols to target areas in biomedical applications.
dc.description24
dc.description3543-53
dc.languageeng
dc.relationBiomaterials
dc.relationBiomaterials
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectBiocompatible Materials
dc.subjectCalorimetry
dc.subjectDelayed-action Preparations
dc.subjectDrug Carriers
dc.subjectHot Temperature
dc.subjectHydrogels
dc.subjectMaterials Testing
dc.subjectMolecular Structure
dc.subjectNitric Oxide
dc.subjectNitric Oxide Donors
dc.subjectPhotochemistry
dc.subjectPoloxamer
dc.subjectS-nitrosothiols
dc.subjectSurface-active Agents
dc.titleThermal And Photochemical Nitric Oxide Release From S-nitrosothiols Incorporated In Pluronic F127 Gel: Potential Uses For Local And Controlled Nitric Oxide Release.
dc.typeArtículos de revistas


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