Lymphocyte Subpopulations During Cytomegalovirus Disease In Renal Transplant Recipients.

dc.creatorCastro, S M
dc.creatorSporleder, H
dc.creatorSchröeder, R
dc.creatorSantos, A
dc.creatorGarcia, V
dc.creatorNeumann, J
dc.creatorCosta, S C B
dc.date2003-Jun
dc.date2015-11-27T12:52:11Z
dc.date2015-11-27T12:52:11Z
dc.date.accessioned2018-03-29T00:57:32Z
dc.date.available2018-03-29T00:57:32Z
dc.identifierBrazilian Journal Of Medical And Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas / Sociedade Brasileira De Biofísica ... [et Al.]. v. 36, n. 6, p. 795-805, 2003-Jun.
dc.identifier0100-879X
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/12792710
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/195410
dc.identifier12792710
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1295643
dc.descriptionWe have determined the number of circulating T, B and natural killer cells in renal transplant recipients in order to detect changes during cytomegalovirus (CMV) infections. Serial blood samples were taken from 61 patients on standard triple immunosuppression therapy (cyclosporin A, azathioprine and prednisone). Using two-color flow cytometry analysis, the absolute number of CD3+, CD4+, CD8+, CD19+, CD3+HLA-DR+ and CD16+56+ cells was determined. Forty-eight patients (78.7%) developed active CMV infection, and all of them subsequently recovered. Twenty of the infected patients (32.8%) presented symptoms compatible with CMV disease during the infectious process. The number of lymphocytes and their main subpopulations were normal before the onset of CMV disease. During the disease there was a decrease followed by a significant increase (P<0.005) in the number of CD3+, CD4+, CD8+ and CD3+HLA-DR+ cells. No significant changes were observed in natural killer cells or B lymphocytes during the disease. We conclude, as observed in all viremic patients recovering from infection, that recovery is associated with an increase in the number of T cell subsets. The monitoring of different lymphocyte subsets along with antigenemia can be extremely useful in the detection of patients at high risk of developing CMV symptoms, allowing the early introduction of antiviral therapy or the reduction of immunosuppression therapy.
dc.description36
dc.description795-805
dc.languageeng
dc.relationBrazilian Journal Of Medical And Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas / Sociedade Brasileira De Biofísica ... [et Al.]
dc.relationBraz. J. Med. Biol. Res.
dc.rightsaberto
dc.rights
dc.sourcePubMed
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectAnalysis Of Variance
dc.subjectB-lymphocytes
dc.subjectCytomegalovirus Infections
dc.subjectFemale
dc.subjectFlow Cytometry
dc.subjectHumans
dc.subjectImmunity, Cellular
dc.subjectImmunosuppressive Agents
dc.subjectKidney Transplantation
dc.subjectKiller Cells, Natural
dc.subjectLymphocyte Activation
dc.subjectLymphocytes
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectT-lymphocytes
dc.titleLymphocyte Subpopulations During Cytomegalovirus Disease In Renal Transplant Recipients.
dc.typeArtículos de revistas


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