Opposite Effects Of Mn(iii) And Fe(iii) Forms Of Meso-tetrakis(4-n-methyl Pyridiniumyl) Porphyrins On Isolated Rat Liver Mitochondria.

dc.creatorNepomuceno, M F
dc.creatorTabak, M
dc.creatorVercesi, A E
dc.date2002-Feb
dc.date2015-11-27T12:49:32Z
dc.date2015-11-27T12:49:32Z
dc.date.accessioned2018-03-29T00:57:01Z
dc.date.available2018-03-29T00:57:01Z
dc.identifierJournal Of Bioenergetics And Biomembranes. v. 34, n. 1, p. 41-7, 2002-Feb.
dc.identifier0145-479X
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/11860179
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/195276
dc.identifier11860179
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1295509
dc.descriptionThe relevance of porphyrins as therapeutic drugs targeted to mitochondria has been widely recognized. In this work, we studied the action of meso-tetrakis porphyrins (TMPyP) on respiring rat liver mitochondria. Mn(III)TMPyP exerted a protective effect against lipid peroxidation induced by Fe(II) or the azo initiator 4,4'-azobis(4-cyanopentanoic acid) (ABCPA), which partition in the hydrophobic phospholipid moiety, and 2,2'-azobis(2-amidinepropane)dihydrochloride (ABAP), which partitions in the aqueous phase. In contrast, Fe(III)TMPyP itself induced an intense lipid peroxidation, accompanied by mitochondrial permeability transition. Both mesoporphyrins studied promoted a release of mitochondrial state-4 respiration, in the concentration range of 1.0-20 microM. Based on the relative effects of Mn(III)TMPyP against ABAP and ABCPA-induced lipid peroxidation, we believe that meso-tetrakis porphyrins must concentrate preferably at membrane-water interfaces.
dc.description34
dc.description41-7
dc.languageeng
dc.relationJournal Of Bioenergetics And Biomembranes
dc.relationJ. Bioenerg. Biomembr.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectDose-response Relationship, Drug
dc.subjectIntracellular Membranes
dc.subjectIron
dc.subjectLipid Peroxidation
dc.subjectManganese
dc.subjectMetalloporphyrins
dc.subjectMitochondria, Liver
dc.subjectOxidative Phosphorylation
dc.subjectOxygen Consumption
dc.subjectPermeability
dc.subjectPorphyrins
dc.subjectRats
dc.subjectRats, Wistar
dc.titleOpposite Effects Of Mn(iii) And Fe(iii) Forms Of Meso-tetrakis(4-n-methyl Pyridiniumyl) Porphyrins On Isolated Rat Liver Mitochondria.
dc.typeArtículos de revistas


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