Methylene Tetrahydrofolate Reductase Gene Mutation Together With Anticardiolipin Antibody During Pregnancy: A Case Report.

dc.creatorCouto, Egle
dc.creatorBarini, Ricardo
dc.creatorNomura, Marcelo Luís
dc.creatorAnnichino-Bizzacchi, Joyce Maria
dc.date2002-Sep
dc.date2015-11-27T12:49:22Z
dc.date2015-11-27T12:49:22Z
dc.date.accessioned2018-03-29T00:56:41Z
dc.date.available2018-03-29T00:56:41Z
dc.identifierSão Paulo Medical Journal = Revista Paulista De Medicina. v. 120, n. 5, p. 152-3, 2002-Sep.
dc.identifier1516-3180
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/12436152
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/195191
dc.identifier12436152
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1295424
dc.descriptionHigh plasmatic homocysteine levels have been associated with arterial and venous thrombosis. The C677T methylene tetrahydrofolate reductase (MTHFR) gene mutation is one of the known causes for high homocysteine levels in plasma. Anticardiolipin antibody (ACA) is also associated with thrombosis and, along with other clinical complications such as recurrent abortion and stillbirth, is part of the antiphospholipid syndrome. Case report. A 19-year-old woman with two gestations and one parity (G2P1) had exhibited deep venous thrombosis in her previous puerperal period. Investigation of thrombophilic factors revealed ACA-IgM and heterozygous C677T mutation in the MTHFR gene. Lupus anticoagulant, protein C, protein S and antithrombin III deficiencies, and Leiden factor V and the G20210A mutation in the prothrombin gene, were not detected. The patient received 55,000 IU of subcutaneous heparin daily, from the 15th to the 36th week of pregnancy, when vaginal delivery took place. There were no clinical complications during the puerperal period and she was discharged three days after delivery, while still using oral anticoagulants.
dc.description120
dc.description152-3
dc.languageeng
dc.relationSão Paulo Medical Journal = Revista Paulista De Medicina
dc.relationSao Paulo Med J
dc.rightsaberto
dc.rights
dc.sourcePubMed
dc.subjectAdult
dc.subjectAntibodies, Anticardiolipin
dc.subjectAnticoagulants
dc.subjectEnzyme-linked Immunosorbent Assay
dc.subjectFemale
dc.subjectHeparin
dc.subjectHumans
dc.subjectMethylenetetrahydrofolate Reductase (nadph2)
dc.subjectOxidoreductases Acting On Ch-nh Group Donors
dc.subjectPregnancy
dc.subjectPregnancy Complications, Hematologic
dc.subjectVenous Thrombosis
dc.titleMethylene Tetrahydrofolate Reductase Gene Mutation Together With Anticardiolipin Antibody During Pregnancy: A Case Report.
dc.typeArtículos de revistas


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