Antiulcerogenic Activity Of Some Sesquiterpene Lactones Isolated From Artemisia Annua.

dc.creatorFoglio, Mary Ann
dc.creatorDias, Patrícia Corrêa
dc.creatorAntônio, Marcia Aparecida
dc.creatorPossenti, Ana
dc.creatorRodrigues, Rodney Alexandre Ferreira
dc.creatorda Silva, Erica Ferreira
dc.creatorRehder, Vera Lúcia Garcia
dc.creatorde Carvalho, João Ernesto
dc.date2002-Jun
dc.date2015-11-27T12:49:08Z
dc.date2015-11-27T12:49:08Z
dc.date.accessioned2018-03-29T00:56:15Z
dc.date.available2018-03-29T00:56:15Z
dc.identifierPlanta Medica. v. 68, n. 6, p. 515-8, 2002-Jun.
dc.identifier0032-0943
dc.identifier10.1055/s-2002-32570
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/12094294
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/195077
dc.identifier12094294
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1295310
dc.descriptionArtemisinin 1, dihydro-epideoxyarteannuin B 2 and deoxyartemisinin 3 were isolated from the sequiterpene lactone-enriched fraction obtained from the crude ethanolic extract of Artemisia annua L. These compounds were tested on ethanol and indomethacin-induced ulcer models. Compound 1 did not afford cytoprotection under the experimental models tested. Only compounds 2 and 3 decreased the ulcerative lesion index produced by ethanol and indomethacin in rats. These compounds did not demonstrate antiulcerogenic activity when tested on the ethanol-induced ulcer model, with previous administration of indomethacin, suggesting that the antiulcerogenic activity is a consequence of prostaglandin synthesis increase.
dc.description68
dc.description515-8
dc.languageeng
dc.relationPlanta Medica
dc.relationPlanta Med.
dc.rightsaberto
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectAnti-ulcer Agents
dc.subjectArtemisinins
dc.subjectAsteraceae
dc.subjectCarbenoxolone
dc.subjectCimetidine
dc.subjectDrug Interactions
dc.subjectEthanol
dc.subjectIndomethacin
dc.subjectMale
dc.subjectPhytotherapy
dc.subjectPlant Extracts
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectSesquiterpenes
dc.subjectStomach
dc.subjectStomach Ulcer
dc.titleAntiulcerogenic Activity Of Some Sesquiterpene Lactones Isolated From Artemisia Annua.
dc.typeArtículos de revistas


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