Insulin Modulates Leptin-induced Stat3 Activation In Rat Hypothalamus.

dc.creatorCarvalheira, J B
dc.creatorSiloto, R M
dc.creatorIgnacchitti, I
dc.creatorBrenelli, S L
dc.creatorCarvalho, C R
dc.creatorLeite, A
dc.creatorVelloso, L A
dc.creatorGontijo, J A
dc.creatorSaad, M J
dc.date2001-Jul
dc.date2015-11-27T12:29:21Z
dc.date2015-11-27T12:29:21Z
dc.date.accessioned2018-03-29T00:56:07Z
dc.date.available2018-03-29T00:56:07Z
dc.identifierFebs Letters. v. 500, n. 3, p. 119-24, 2001-Jul.
dc.identifier0014-5793
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/11445068
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/195043
dc.identifier11445068
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1295276
dc.descriptionInsulin and leptin have overlapping effects in the control of energy homeostasis, but the molecular basis of this synergism is unknown. Insulin signals through a receptor tyrosine kinase that phosphorylates and activates the docking proteins IRSs (insulin receptor substrates), whereas the leptin receptor and its associated protein tyrosine kinase JAK2 (Janus kinase 2) mediate phosphorylation and activation of the transcription factor STAT3 (signal transducer and activator of transcription). Here, we present evidence for the integration of leptin and insulin signals in the hypothalamus. Insulin induced JAK2 tyrosine phosphorylation, leptin receptor phosphorylation which, in the presence of leptin, augmented the interaction between STAT3 and this receptor. Insulin also increased the leptin-induced phosphorylation of STAT3 and its activation. These results indicate that insulin modulates the leptin signal transduction pathway, and may provide a molecular basis for the coordinated effects of insulin and leptin in feeding behavior and weight control.
dc.description500
dc.description119-24
dc.languageeng
dc.relationFebs Letters
dc.relationFEBS Lett.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectBlotting, Western
dc.subjectCarrier Proteins
dc.subjectDna-binding Proteins
dc.subjectHypothalamus
dc.subjectInjections, Intraventricular
dc.subjectInsulin
dc.subjectJanus Kinase 2
dc.subjectLeptin
dc.subjectMale
dc.subjectModels, Biological
dc.subjectPhosphorylation
dc.subjectProtein-tyrosine Kinases
dc.subjectProto-oncogene Proteins
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectReceptor, Insulin
dc.subjectReceptors, Cell Surface
dc.subjectReceptors, Leptin
dc.subjectStat3 Transcription Factor
dc.subjectSignal Transduction
dc.subjectTrans-activators
dc.titleInsulin Modulates Leptin-induced Stat3 Activation In Rat Hypothalamus.
dc.typeArtículos de revistas


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