Efficacy Of Clobazam As Add-on Therapy In Patients With Refractory Partial Epilepsy.

dc.creatorMontenegro, M A
dc.creatorCendes, F
dc.creatorNoronha, A L
dc.creatorMory, S B
dc.creatorCarvalho, M I
dc.creatorMarques, L H
dc.creatorGuerreiro, C A
dc.date2001-Apr
dc.date2015-11-27T12:29:20Z
dc.date2015-11-27T12:29:20Z
dc.date.accessioned2018-03-29T00:56:06Z
dc.date.available2018-03-29T00:56:06Z
dc.identifierEpilepsia. v. 42, n. 4, p. 539-42, 2001-Apr.
dc.identifier0013-9580
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/11440350
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/195038
dc.identifier11440350
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1295271
dc.descriptionClobazam (CLB) has an important antiepileptic effect and is less expensive than the new antiepileptic drugs (AEDs), but still has not been considered as first-line drug in the treatment of epilepsy. We evaluated the efficacy of CLB as add-on therapy in patients with refractory partial epilepsy. This was an open, retrospective study, conducted at the epilepsy clinic of our university hospital. All patients had chronic epilepsy and were being evaluated for epilepsy surgery. CLB was introduced as add-on therapy (starting with 10 mg/ day) in patients with previous failure of at least two AEDs. Information was obtained from clinical notes and follow-up visits. We evaluated 97 patients, 37 men and 60 women. Ages ranged from 15 to 70 years (mean, 35.8 years). Etiology of epilepsy was hippocampal atrophy in 67 (69%), cortical dysgenesis in nine (9.3%), and other etiologies in nine (9.3%). In 12 (12.3%) patients, the etiology of epilepsy was not identified despite clinical and neurologic investigation. Patients used CLB for a period ranging from 1 month to 7 years and 9 months (mean, 16.7 months) with doses ranging from 10 to 60 mg/day (mean, 29.7 mg/day). Seven (7.2%) patients were seizure free, 48 (49.4%) had > or =50% of improvement in seizure control, 39 (40.2%) had <50% of improvement in seizure control, and in three (3.1%), no data were available. We conclude that CLB may have efficacy equivalent to that of the new AEDs when used as add-on therapy in patients with refractory epilepsy. CLB should be considered an economic alternative in the treatment of patients with refractory epilepsy.
dc.description42
dc.description539-42
dc.languageeng
dc.relationEpilepsia
dc.relationEpilepsia
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectAnti-anxiety Agents
dc.subjectAnticonvulsants
dc.subjectBenzodiazepines
dc.subjectDrug Administration Schedule
dc.subjectDrug Therapy, Combination
dc.subjectEpilepsies, Partial
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectRetrospective Studies
dc.subjectSurvival Analysis
dc.subjectTreatment Outcome
dc.titleEfficacy Of Clobazam As Add-on Therapy In Patients With Refractory Partial Epilepsy.
dc.typeArtículos de revistas


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