Stimulation Of Myelopoiesis In Listeria Monocytogenes-infected Mice By An Aggregated Polymer Isolated From Aspergillus Oryzae.

dc.creatorde Melo, A
dc.creatorJusto, G Z
dc.creatorde Souza Queiroz, M L
dc.date2001-Jan
dc.date2015-11-27T12:29:16Z
dc.date2015-11-27T12:29:16Z
dc.date.accessioned2018-03-29T00:55:56Z
dc.date.available2018-03-29T00:55:56Z
dc.identifierHuman & Experimental Toxicology. v. 20, n. 1, p. 38-45, 2001-Jan.
dc.identifier0960-3271
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/11339624
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/194996
dc.identifier11339624
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1295229
dc.descriptionIn this work, we investigated the effects of the proteic aggregated polymer of magnesium ammonium phospholinoleate-palmitoleate anhydride (MAPA) isolated from Aspergillus oryzae on the growth and differentiation of bone marrow granulocyte-macrophage progenitor cells (CFU-GM) in Listeriamonocytogenes-infected mice. A significant reduction in the CFU-GM number was observed in the initial phase of infection with a sublethal dose of Listeria. Treatment of mice with 0.5, 2.0 and 5.0 mg/kg MAPA for 7 days prior to infection significantly stimulated myelopoiesis in a dose-dependent manner. Moreover, treatment with 0.5 and 5.0 mg/kg MAPA resulted in 30% and 40% cures of mice lethally infected with Listeria, respectively. MAPA added directly to the culture dishes hardly affected colony formation by bone marrow cells, suggesting an indirect effect ofthis compound on myelopoiesis in vivo. In summary, the data show that MAPA can modulate the CFU-GM generation and antibacterial resistance in listeriosis. As the ability of hematopoietic tissues to produce phagocytes is of particular significance to mediate resistance to Listeria, the promotion of bone marrow CFU-GM by MAPA may contribute to a rapid restoration of phagocyte numbers in infected sites, thus mitigating the course of infection.
dc.description20
dc.description38-45
dc.languageeng
dc.relationHuman & Experimental Toxicology
dc.relationHum Exp Toxicol
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectAspergillus Oryzae
dc.subjectBone Marrow Cells
dc.subjectGranulocyte-macrophage Colony-stimulating Factor
dc.subjectInjections, Subcutaneous
dc.subjectLeukopoiesis
dc.subjectListeriosis
dc.subjectMale
dc.subjectMice
dc.subjectMice, Inbred Balb C
dc.subjectPolymers
dc.subjectRecombinant Proteins
dc.subjectStem Cells
dc.subjectSurvival Analysis
dc.titleStimulation Of Myelopoiesis In Listeria Monocytogenes-infected Mice By An Aggregated Polymer Isolated From Aspergillus Oryzae.
dc.typeArtículos de revistas


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