Evaluation Of Caesalpinia Ferrea Extract On Bone Marrow Hematopoiesis In The Murine Models Of Listeriosis And Ehrlich Ascites Tumor.

dc.creatorQueiroz, M L
dc.creatorJusto, G Z
dc.creatorValadares, M C
dc.creatorPereira-da-silva, F R
dc.date2001-Aug
dc.date2015-11-27T12:29:02Z
dc.date2015-11-27T12:29:02Z
dc.date.accessioned2018-03-29T00:55:29Z
dc.date.available2018-03-29T00:55:29Z
dc.identifierImmunopharmacology And Immunotoxicology. v. 23, n. 3, p. 367-82, 2001-Aug.
dc.identifier0892-3973
dc.identifier10.1081/IPH-100107337
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/11694028
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/194876
dc.identifier11694028
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1295109
dc.descriptionThe capacity of hematopoietic tissues to produce and mobilize phagocytes to the site of infection and tumor growth is of central importance to mediate the early immunological response. In this perspective, studies from our laboratory have defined Listeria monocytogenes infection and the Ehrlich ascites tumor (EAT) as useful models to investigate the effects of natural compounds on the growth and differentiation of granulocyte-macrophage progenitor cells (CFU-GM). As expected, a significant reduction in the number of bone marrow CFU-GM was observed in the initial stages of infection with a sublethal dose of Listeria. Similarly, the bone marrow CFU-GM decreased sharply 4 days after the EAT transplantation. Treatment of infected and tumor-bearing mice with 500 and 1,000 mg/kg of Caesalpinia ferrea aqueous extract, given 3 times orally, significantly stimulated myelopoiesis, whereas no effects were observed with the 250 mg/kg dose. Similar results were obtained in normal mice. The administration of the two higher doses of the extract also protected 15-20% of mice from a lethal dose of Listeria and significantly prolonged survival of EAT-bearing mice. In summary, these results demonstrate that C. ferrea extract acts as a positive regulator of myelopoiesis, and suggest that the therapeutic effect of C. ferrea may be partially mediated by this action.
dc.description23
dc.description367-82
dc.languageeng
dc.relationImmunopharmacology And Immunotoxicology
dc.relationImmunopharmacol Immunotoxicol
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAdministration, Oral
dc.subjectAnimals
dc.subjectCaesalpinia
dc.subjectCarcinoma, Ehrlich Tumor
dc.subjectColony-forming Units Assay
dc.subjectDose-response Relationship, Drug
dc.subjectGranulocytes
dc.subjectHematopoiesis
dc.subjectListeriosis
dc.subjectMacrophages
dc.subjectMice
dc.subjectMice, Inbred Balb C
dc.subjectPhytotherapy
dc.subjectPlant Extracts
dc.titleEvaluation Of Caesalpinia Ferrea Extract On Bone Marrow Hematopoiesis In The Murine Models Of Listeriosis And Ehrlich Ascites Tumor.
dc.typeArtículos de revistas


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