Development Of A Behavioral Model Of Tmj Pain In Rats: The Tmj Formalin Test.

dc.creatorRoveroni, R C
dc.creatorParada, C A
dc.creatorCecília, M
dc.creatorVeiga, F A
dc.creatorTambeli, C H
dc.date2001-Nov
dc.date2015-11-27T12:29:02Z
dc.date2015-11-27T12:29:02Z
dc.date.accessioned2018-03-29T00:55:28Z
dc.date.available2018-03-29T00:55:28Z
dc.identifierPain. v. 94, n. 2, p. 185-91, 2001-Nov.
dc.identifier0304-3959
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/11690732
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/194875
dc.identifier11690732
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1295108
dc.descriptionTemporomandibular joint (TMJ) pain conditions are poorly understood. Since formalin is a noxious stimulus widely used in animal behavioral experiments for studying pain mechanisms, the aim of this study was to develop a behavioral model to study the TMJ pain conditions by characterizing the nociceptive behavioral responses induced by the injection of formalin into the TMJ region of rats. NaCl (0.9%) or different concentrations of formalin (0.5, 1.5, 2.5 or 5%) were administrated into the TMJ region. The formalin-induced behavioral responses characterized by moving the mandible, rubbing the orofacial region and flinching the head quickly were quantified for 45 min. The TMJ injection of formalin significantly increased the asymmetrical orofacial rubbing and head flinching behaviors, but not the movement of the mandible with concentrations of 1.5% and above (P<0.05, Dunn's test) when compared with the NaCl (0.9%) injection. These responses were significantly reduced (P<0.05, Mann-Whitney test) by the co-application of lidocaine N-ethyl bromide quaternary salt, QX-314 (2%), and by the administration of intraperitoneal morphine (4 mg/kg) 30 min prior to the TMJ formalin injection. This study demonstrates that the injection of formalin into the TMJ region of rats produces quantitative nociceptive behaviors constituting a novel behavioral model for TMJ pain.
dc.description94
dc.description185-91
dc.languageeng
dc.relationPain
dc.relationPain
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAnalgesics, Opioid
dc.subjectAnesthetics, Local
dc.subjectAnimals
dc.subjectBehavior, Animal
dc.subjectDisease Models, Animal
dc.subjectLidocaine
dc.subjectMale
dc.subjectMorphine
dc.subjectNociceptors
dc.subjectPain
dc.subjectPain Measurement
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectTemporomandibular Joint
dc.titleDevelopment Of A Behavioral Model Of Tmj Pain In Rats: The Tmj Formalin Test.
dc.typeArtículos de revistas


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