Turner's Syndrome And Thyroid Disease: A Transverse Study Of Pediatric Patients In Brazil.

dc.creatorMedeiros, C C
dc.creatorMarini, S H
dc.creatorBaptista, M T
dc.creatorGuerra, G
dc.creatorMaciel-Guerra, A T
dc.date2000-Apr
dc.date2015-11-27T12:22:58Z
dc.date2015-11-27T12:22:58Z
dc.date.accessioned2018-03-29T00:54:57Z
dc.date.available2018-03-29T00:54:57Z
dc.identifierJournal Of Pediatric Endocrinology & Metabolism : Jpem. v. 13, n. 4, p. 357-62, 2000-Apr.
dc.identifier0334-018X
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/10776989
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/194740
dc.identifier10776989
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1294973
dc.descriptionAn increased prevalence of autoimmune thyroid disease (AITD) has been described in Turner's syndrome (TS), but the extent of this association is still controversial. Some studies also suggest that AITD is more frequent among patients with X-isochromosome. In order to determine the prevalence of AITD among girls with TS, and to look for an association with age and karyotype, we evaluated 71 patients with a mean age of 11.4 years (range 0-19.9). 15.5% (11/71) were hypothyroid, 17 (23.9%) were positive for thyroid peroxidase (TPO) and/or thyroglobulin (Tg) antibodies, and 24 (33.8%) had thyromegaly. No abnormality was observed before 4 years, and the highest frequencies were observed after 16 years. There were no significant differences concerning thyroid findings among patients with a 45,X karyotype, mosaics, and structural rearrangements. Half of the patients (35/71) exhibited one or more abnormalities, which demonstrates the importance of careful evaluation of thyroid function in all girls with TS.
dc.description13
dc.description357-62
dc.languageeng
dc.relationJournal Of Pediatric Endocrinology & Metabolism : Jpem
dc.relationJ. Pediatr. Endocrinol. Metab.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAutoantibodies
dc.subjectAutoimmune Diseases
dc.subjectBrazil
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectFemale
dc.subjectHumans
dc.subjectHypothyroidism
dc.subjectInfant
dc.subjectInfant, Newborn
dc.subjectIodide Peroxidase
dc.subjectThyroglobulin
dc.subjectTurner Syndrome
dc.subjectX Chromosome
dc.titleTurner's Syndrome And Thyroid Disease: A Transverse Study Of Pediatric Patients In Brazil.
dc.typeArtículos de revistas


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