Artificial Articular Cartilage: Mechanoelectrical Transduction Under Dynamic Compressive Loading.

dc.creatorMalmonge, S M
dc.creatorArruda, A C
dc.date2000-Mar
dc.date2015-11-27T12:22:57Z
dc.date2015-11-27T12:22:57Z
dc.date.accessioned2018-03-29T00:54:55Z
dc.date.available2018-03-29T00:54:55Z
dc.identifierArtificial Organs. v. 24, n. 3, p. 174-8, 2000-Mar.
dc.identifier0160-564X
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/10759634
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/194728
dc.identifier10759634
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1294961
dc.descriptionThe search for biomaterials to be used as an artificial articular cartilage in joint restoration is a challenging research area. Because the articular cartilage plays a fundamental role in joint function, the biomaterial has to be able to mimic the behavior of the natural healthy surface. Articular cartilage is a biphasic material composed by a solid extracellular matrix and a fluid phase, the synovial fluid. When the tissue is pressed, there is a mechanoelectrical transduction that is believed to modulate the cellular activity of chondrocytes, being fundamental for tissue repair. This work aimed at the development of hydrogels for use as an artificial articular cartilage. Hydrogels with negative groups fixed in the macromolecular network were obtained by copolymerizing 2-hydroxyethyl methacrylate with acrylic acid. The obtained hydrogels showed a mechanoelectrical transduction under dynamic compressive loading with potential amplitude increasing with fixed charge density values.
dc.description24
dc.description174-8
dc.languageeng
dc.relationArtificial Organs
dc.relationArtif Organs
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAcrylates
dc.subjectBiocompatible Materials
dc.subjectBiomechanical Phenomena
dc.subjectCartilage, Articular
dc.subjectChemistry, Physical
dc.subjectChondrocytes
dc.subjectElectrochemistry
dc.subjectExtracellular Matrix
dc.subjectHumans
dc.subjectHydrogels
dc.subjectMethacrylates
dc.subjectPhysicochemical Phenomena
dc.subjectProstheses And Implants
dc.subjectProsthesis Design
dc.subjectStress, Mechanical
dc.subjectSynovial Fluid
dc.subjectWeight-bearing
dc.titleArtificial Articular Cartilage: Mechanoelectrical Transduction Under Dynamic Compressive Loading.
dc.typeArtículos de revistas


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