Platelet-derived Growth Factor/insulin-like Growth Factor-1 Combination And Bone Regeneration Around Implants Placed Into Extraction Sockets: A Histometric Study In Dogs.

dc.creatorStefani, C M
dc.creatorMachado, M A
dc.creatorSallum, E A
dc.creatorSallum, A W
dc.creatorToledo, S
dc.creatorNociti, F H
dc.date2000
dc.date2015-11-27T12:22:51Z
dc.date2015-11-27T12:22:51Z
dc.date.accessioned2018-03-29T00:54:42Z
dc.date.available2018-03-29T00:54:42Z
dc.identifierImplant Dentistry. v. 9, n. 2, p. 126-31, 2000.
dc.identifier1056-6163
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/11314699
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/194676
dc.identifier11314699
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1294909
dc.descriptionThis study evaluated, by histometric analysis, the wound healing process of bone around implants placed into extraction sockets with or without the concurrent application of a combination of platelet-derived growth factor (PDGF) and insulin-like growth factor (IGF-1). Mandibular premolars were removed, and 32 implants were inserted in eight dogs. Before insertion, two implants received a single application of 5 micrograms/mL of PDGF and IGF-1 delivered in 0.10 mL of 4% methylcellulose gel or 0.10 mL of 4% methylcellulose gel only as a control. To label regenerated bone, a 2% calcein green solution was administered by intramuscular injection at 0, 7, 15, 30, 45, 60, and 75 days after implant insertion. Three, 8, and 12 weeks after implant insertion, undecalcified sections were obtained, and the degree of bone contact with the implant surface, the bone area, and the intensity of bone labeling were measured into the limits of the threads of the implant. Greater extension of bone/implant contact (paired t test, P < .05) was observed in test (22.4% +/- 13.7%) than in control (17.2% +/- 13.6%) implants at 3 weeks. One-way ANOVA revealed a higher intensity of bone labeling (P < .05) at 3 weeks than at 12 weeks (127.8 +/- 42.59 and 56.7 +/- 26.34, gray scale values) for test implants. Within the limits of the present study, it was concluded that the combination of PDGF/IGF-I actively took part in the initial phase of bone repair.
dc.description9
dc.description126-31
dc.languageeng
dc.relationImplant Dentistry
dc.relationImplant Dent
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAnalysis Of Variance
dc.subjectAnimals
dc.subjectBicuspid
dc.subjectBone Regeneration
dc.subjectDental Implantation, Endosseous
dc.subjectDental Implants
dc.subjectDogs
dc.subjectDrug Combinations
dc.subjectFluoresceins
dc.subjectFluorescent Dyes
dc.subjectFollow-up Studies
dc.subjectGels
dc.subjectInsulin-like Growth Factor I
dc.subjectMandible
dc.subjectMethylcellulose
dc.subjectOsseointegration
dc.subjectPlatelet-derived Growth Factor
dc.subjectRandom Allocation
dc.subjectStatistics As Topic
dc.subjectSurface Properties
dc.subjectTooth Extraction
dc.subjectTooth Socket
dc.subjectWound Healing
dc.titlePlatelet-derived Growth Factor/insulin-like Growth Factor-1 Combination And Bone Regeneration Around Implants Placed Into Extraction Sockets: A Histometric Study In Dogs.
dc.typeArtículos de revistas


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