Anti-leishmanial Activity Of Neolignans From Virola Species And Synthetic Analogues.

dc.creatorBarata, L E
dc.creatorSantos, L S
dc.creatorFerri, P H
dc.creatorPhillipson, J D
dc.creatorPaine, A
dc.creatorCroft, S L
dc.date2000-Nov
dc.date2015-11-27T12:22:48Z
dc.date2015-11-27T12:22:48Z
dc.date.accessioned2018-03-29T00:54:36Z
dc.date.available2018-03-29T00:54:36Z
dc.identifierPhytochemistry. v. 55, n. 6, p. 589-95, 2000-Nov.
dc.identifier0031-9422
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/11130669
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/194647
dc.identifier11130669
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1294880
dc.descriptionSurinamensin, a neolignan isolated from Virola surinamensis, 3,4,5-trimethoxy-8-[2',6'-dimethoxy-4'-(E)-propenylphenoxy]-phenylpropane, a neolignan isolated from Virola pavonis, and 25 of its synthetic analogues or correlated substances with ether linkages and their corresponding C-8 sulphur and nitrogen analogues, were tested for activity against Leishmania donovani amastigotes and promastigotes in vitro. Some were active against L. donovani promastigotes at 30 microM but inactive against intracellular amastigotes. The natural neolignan from V. pavonis was active against promastigotes at 100 microM. The highest selective activity was found in those compounds with sulphur bridges. The beta-ketosulfide (3,4-dimethoxy)-8-(4'-methylthiophenoxy)-propiophenone produced 42% inhibition of L. donovani amastigotes in the liver of BALB/c mice at 100 mg/kg given once daily for five consecutive days (P>0.05).
dc.description55
dc.description589-95
dc.languageeng
dc.relationPhytochemistry
dc.relationPhytochemistry
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAngiosperms
dc.subjectAnimals
dc.subjectAnisoles
dc.subjectAntiprotozoal Agents
dc.subjectDisease Models, Animal
dc.subjectDrug Evaluation, Preclinical
dc.subjectFemale
dc.subjectLeishmania Donovani
dc.subjectLeishmaniasis, Visceral
dc.subjectLignans
dc.subjectMice
dc.subjectMice, Inbred Balb C
dc.titleAnti-leishmanial Activity Of Neolignans From Virola Species And Synthetic Analogues.
dc.typeArtículos de revistas


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