Predisposition To Metabolic Acidosis Induced By Topiramate.

dc.creatorMontenegro, M A
dc.creatorGuerreiro, M M
dc.creatorScotoni, A E
dc.creatorGuerreiro, C A
dc.date2000-Dec
dc.date2015-11-27T12:22:47Z
dc.date2015-11-27T12:22:47Z
dc.date.accessioned2018-03-29T00:54:33Z
dc.date.available2018-03-29T00:54:33Z
dc.identifierArquivos De Neuro-psiquiatria. v. 58, n. 4, p. 1021-4, 2000-Dec.
dc.identifier0004-282X
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/11105067
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/194634
dc.identifier11105067
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1294867
dc.descriptionMetabolic acidosis induced by topiramate is a well documented but infrequent adverse event. The objective was to demonstrate the lowering of carbon dioxide serum levels, which is usually asymptomatic but may facilitate the occurrence of metabolic acidosis in patients using topiramate. We evaluated, prospectively, the carbon dioxide serum levels of 18 patients seen at the epilepsy clinic of our university hospital, before and 3 months after introducing topiramate. Five patients were female and 13 were male, age ranging from 2 to 16 years old (mean=9. 3). Carbon dioxide mean serum levels were 25 and 21.2 mmol/L (normal = 22 to 30), before and 3 months after introducing topiramate, respectively. Dose ranged from 2.08 to 11.76 mg/kg/day (mean=6. 7mg/kg/day). Adverse events were anorexia, nausea and somnolence. We conclude that the lowering of carbon dioxide serum levels induced by topiramate is mostly asymptomatic, but may facilitate the occurrence of metabolic acidosis. Since patients in use of topiramate have refractory epilepsy, they may need epilepsy surgery, and must be carefully monitored for the risk of metabolic acidosis during surgery.
dc.description58
dc.description1021-4
dc.languageeng
dc.relationArquivos De Neuro-psiquiatria
dc.relationArq Neuropsiquiatr
dc.rightsaberto
dc.rights
dc.sourcePubMed
dc.subjectAcidosis
dc.subjectAdolescent
dc.subjectAnticonvulsants
dc.subjectCarbon Dioxide
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectDisease Susceptibility
dc.subjectEpilepsy
dc.subjectFemale
dc.subjectFructose
dc.subjectHumans
dc.subjectInfant
dc.subjectMale
dc.subjectProspective Studies
dc.titlePredisposition To Metabolic Acidosis Induced By Topiramate.
dc.typeArtículos de revistas


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