Collagen Fiber Reorganization In The Rat Ventral Prostate Following Androgen Deprivation: A Possible Role For Smooth Muscle Cells.

dc.creatorVilamaior, P S
dc.creatorFelisbino, S L
dc.creatorTaboga, S R
dc.creatorCarvalho, H F
dc.date2000-Nov
dc.date2015-11-27T12:22:44Z
dc.date2015-11-27T12:22:44Z
dc.date.accessioned2018-03-29T00:54:28Z
dc.date.available2018-03-29T00:54:28Z
dc.identifierThe Prostate. v. 45, n. 3, p. 253-8, 2000-Nov.
dc.identifier0270-4137
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/11074528
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/194616
dc.identifier11074528
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1294849
dc.descriptionStroma plays an essential role in glandular function in different systems. In the prostate, it is responsible for the development and maintenance of the differentiated state of the epithelium. The marked reduction in the epithelial compartment of the prostate gland following castration is followed by a similarly important reorganization of the stroma. In this work, we characterized the reorganization of collagen fibers in the ventral prostate of castrated rats. Histochemical tests and immunohistochemistry for type I and III collagens plus confocal microscopy of triple-labeled (collagen III, actin, and DNA) tissue sections were employed. We showed that collagen fibers are composed of type I and type III collagens and that they are progressively concentrated around the epithelial structures (ducts and acini) and become increasingly undulated and folded. Double-labeling of collagen fibers and F-actin demonstrated that smooth muscle cells (SMC) are intimately associated with collagen fibers. The results demonstrated a marked reorganization of the collagen fibers, and suggest an active role of the SMC in the reorganization of the fibrillar components of the stroma.
dc.description45
dc.description253-8
dc.languageeng
dc.relationThe Prostate
dc.relationProstate
dc.rightsfechado
dc.rightsCopyright 2000 Wiley-Liss, Inc.
dc.sourcePubMed
dc.subjectAnimals
dc.subjectCastration
dc.subjectCell Differentiation
dc.subjectCollagen
dc.subjectImmunohistochemistry
dc.subjectMale
dc.subjectMuscle, Smooth
dc.subjectProstate
dc.subjectRats
dc.subjectRats, Wistar
dc.titleCollagen Fiber Reorganization In The Rat Ventral Prostate Following Androgen Deprivation: A Possible Role For Smooth Muscle Cells.
dc.typeArtículos de revistas


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