Hsp72 As A Complementary Protection Against Oxidative Stress Induced By Exercise In The Soleus Muscle Of Rats.

dc.creatorSmolka, M B
dc.creatorZoppi, C C
dc.creatorAlves, A A
dc.creatorSilveira, L R
dc.creatorMarangoni, S
dc.creatorPereira-Da-Silva, L
dc.creatorNovello, J C
dc.creatorMacedo, D V
dc.date2000-Nov
dc.date2015-11-27T12:22:44Z
dc.date2015-11-27T12:22:44Z
dc.date.accessioned2018-03-29T00:54:27Z
dc.date.available2018-03-29T00:54:27Z
dc.identifierAmerican Journal Of Physiology. Regulatory, Integrative And Comparative Physiology. v. 279, n. 5, p. R1539-45, 2000-Nov.
dc.identifier0363-6119
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/11049834
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/194613
dc.identifier11049834
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1294846
dc.descriptionGiven the potential of reactive oxygen species to damage intracellular proteins during subsequent bouts of muscle contractions, it was suggested that, when this production exceeds the antioxidant capacity, the preexisting antioxidant pathways may be complemented by the synthesis of the defense mechanism represented by heat shock proteins (HSPs), stress proteins with the function of repair and maintaining protein folding. To test this hypothesis, we analyzed reactive carbonyl derivatives in plasma and the expression of HSP72 and activities of enzymes from the oxidative and antioxidant defense systems in the soleus muscle of sedentary rats and rats trained by two protocols: continuous and intermittent. We analyzed all three groups at rest and 2 h after acute exercise. After 8 wk of training, the animals from both groups clearly demonstrated higher resistance to exercise. Both trained groups showed significantly higher citrate synthase, catalase, and glutathione reductase activities than the control group (P < 0.01). After acute exercise, catalase and glutathione reductase activities significantly decreased (P < 0.01) and plasma reactive carbonyl derivatives significantly increased (P < 0.05) in the sedentary group, suggesting an oxidative-stress condition as responsible for exhaustion in this group. Finally, after acute exercise, the induction of HSP72 expression occurred only in the sedentary group, suggesting that HSP72 acts as a complementary protective mechanism in exercise-induced oxidative stress.
dc.description279
dc.descriptionR1539-45
dc.languageeng
dc.relationAmerican Journal Of Physiology. Regulatory, Integrative And Comparative Physiology
dc.relationAm. J. Physiol. Regul. Integr. Comp. Physiol.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectCatalase
dc.subjectCitrate (si)-synthase
dc.subjectGlutathione Reductase
dc.subjectHsp72 Heat-shock Proteins
dc.subjectHeat-shock Proteins
dc.subjectMale
dc.subjectMuscle Contraction
dc.subjectMuscle, Skeletal
dc.subjectOxidative Stress
dc.subjectPhysical Exertion
dc.subjectRats
dc.subjectRats, Wistar
dc.titleHsp72 As A Complementary Protection Against Oxidative Stress Induced By Exercise In The Soleus Muscle Of Rats.
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución