Artículos de revistas
Heck Arylation Of Endocyclic Enecarbamates With Diazonium Salts. Improvements And A Concise Enantioselective Synthesis Of (-)-codonopsinine.
Registro en:
Organic Letters. v. 2, n. 20, p. 3039-42, 2000-Oct.
1523-7060
11009340
Autor
Severino, E A
Roque D Correia, C
Institución
Resumen
Total enantioselective synthesis of the natural (-)-codonopsinine was accomplished in seven steps with an overall yield of approximately 16% starting from the five-membered endocyclic enecarbamate 4. The total synthesis features a highly efficient and stereoselective Heck arylation of endocyclic enecarbamate 4 with p-methoxybenzenediazonium tetrafluoroborate and a stereoselective epoxidation/epoxide opening sequence as key steps. 2 3039-42