Detection Of Human Papillomavirus In Laryngeal Squamous Dysplasia And Carcinoma. An In Situ Hybridization And Signal Amplification Study.

dc.creatorBrito, H
dc.creatorVassallo, J
dc.creatorAltemani, A
dc.date2000-Jun
dc.date2015-11-27T12:22:38Z
dc.date2015-11-27T12:22:38Z
dc.date.accessioned2018-03-29T00:54:17Z
dc.date.available2018-03-29T00:54:17Z
dc.identifierActa Oto-laryngologica. v. 120, n. 4, p. 540-4, 2000-Jun.
dc.identifier0001-6489
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/10958409
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/194565
dc.identifier10958409
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1294798
dc.descriptionWe examined the presence of human papillomavirus (HPV) DNA in 65 cases of laryngeal squamous dysplasia and carcinomas using in situ hybridization with signal amplification in paraffin sections. Hybridization was performed with biotinylated DNA probes for HPV 6/11, 16/18, 31/33 and wide-spectrum HPV (6, 11, 16, 30, 31, 45, 51 and 52). HPV DNA was found in 7 cases of the total sample (10.7%); it was also found in 4 out of 45 (8.8%) cases of invasive carcinoma and in 5 out of 33 (15.5%) cases of squamous dysplasia. Morphological signs suggestive of HPV infection were observed in 35.5% of our sample but they were not related to HPV DNA positivity. In conclusion, HPV probably plays little, if any, role in laryngeal carcinogenesis among the population studied.
dc.description120
dc.description540-4
dc.languageeng
dc.relationActa Oto-laryngologica
dc.relationActa Otolaryngol.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 And Over
dc.subjectCarcinoma
dc.subjectDna, Viral
dc.subjectFemale
dc.subjectHumans
dc.subjectIn Situ Hybridization
dc.subjectLaryngeal Neoplasms
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectNucleic Acid Amplification Techniques
dc.subjectPapillomaviridae
dc.subjectPrecancerous Conditions
dc.titleDetection Of Human Papillomavirus In Laryngeal Squamous Dysplasia And Carcinoma. An In Situ Hybridization And Signal Amplification Study.
dc.typeArtículos de revistas


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