Cytokine Profile And Natural Killer Cell Activity In Listeria Monocytogenes Infected Mice Treated Orally With Petiveria Alliacea Extract.

dc.creatorQueiroz, M L
dc.creatorQuadros, M R
dc.creatorSantos, L M
dc.date2000-Aug
dc.date2015-11-27T12:22:37Z
dc.date2015-11-27T12:22:37Z
dc.date.accessioned2018-03-29T00:54:16Z
dc.date.available2018-03-29T00:54:16Z
dc.identifierImmunopharmacology And Immunotoxicology. v. 22, n. 3, p. 501-18, 2000-Aug.
dc.identifier0892-3973
dc.identifier10.3109/08923970009026008
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/10946828
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/194563
dc.identifier10946828
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1294796
dc.descriptionIn this work, we investigated the effects of Petiveria alliacea extract on the production of Th1-type and Th2-type cytokines and on NK cells activity in normal and Listeria monocytogenes infected mice. Our results demonstrated that in normal/non-infected mice P. alliacea administration led to increased levels of Interleukin-2 (IL-2). The infection alone enhanced INF-gamma levels and NK cell activity at 48 and 72 hours of infection. The treatment with five consecutive doses of 1000 mg/kg/day of P. alliacea extract, given previously to infection, led to further increases in IL-2 levels, in relation to normal/non-infected/P. alliacea treated controls, and in INF-gamma levels at 72 h of infection, compared to infected mice. On the other hand, the production of IL-4 and IL-10 were not altered either by the infection or by the treatment with P. alliacea extract. NK cells activity increased at 48 h and 72 h following the inoculation of the bacteria. When mice were treated with P. alliacea previously to infection, NK activity was higher than that observed at 48 h, 72 h and 120 h of infection in the infected animal. Based on these findings we suggest that P. alliacea up-regulates anti-bacterial immune response by enhancing both Th1 function and the activity of NK cells.
dc.description22
dc.description501-18
dc.languageeng
dc.relationImmunopharmacology And Immunotoxicology
dc.relationImmunopharmacol Immunotoxicol
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAdministration, Oral
dc.subjectAngiosperms
dc.subjectAnimals
dc.subjectCytokines
dc.subjectIn Vitro Techniques
dc.subjectInterferon-gamma
dc.subjectInterleukin-10
dc.subjectInterleukin-2
dc.subjectInterleukin-4
dc.subjectKiller Cells, Natural
dc.subjectListeriosis
dc.subjectMale
dc.subjectMice
dc.subjectMice, Inbred Balb C
dc.subjectPlant Extracts
dc.subjectPlants, Medicinal
dc.subjectTh1 Cells
dc.subjectTh2 Cells
dc.titleCytokine Profile And Natural Killer Cell Activity In Listeria Monocytogenes Infected Mice Treated Orally With Petiveria Alliacea Extract.
dc.typeArtículos de revistas


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