Brasil | Artículos de revistas

Study Of The Vaginal Tolerance To Acidform, An Acid-buffering, Bioadhesive Gel.

dc.creatorAmaral, E
dc.creatorFaúndes, A
dc.creatorZaneveld, L
dc.creatorWaller, D
dc.creatorGarg, S
dc.date1999-Dec
dc.date2015-11-27T12:19:48Z
dc.date2015-11-27T12:19:48Z
dc.date.accessioned2018-03-29T00:53:57Z
dc.date.available2018-03-29T00:53:57Z
dc.identifierContraception. v. 60, n. 6, p. 361-6, 1999-Dec.
dc.identifier0010-7824
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/10715372
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/194478
dc.identifier10715372
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1294711
dc.descriptionVaginal tolerance tests were performed with a new potential microbicidal and spermicidal product, an acid-buffering vaginal gel (Acidform) without or with nonoxynol-9 (N-9). The potential advantages over other vaginal products include keeping a low pH, decrease of the irritating effect of N-9 on the cervix or vaginal mucosa associated with greater retention of the product after application, and decreasing messiness as compared to other vaginal products. Three groups of six women were admitted and randomly assigned to use Acidform with 0%, 2.5%, and 5% N-9. Colposcopic evaluation for vulvar, vaginal, and cervical signs of irritation was performed and photographs were taken, following a specific World Health Organization protocol, at time 0, and after 24 h and 6 days of application of the gel. No irritation or symptom was reported by users of Acidform without N-9. A generalized and intense erythema in cervix was observed in 10 of 12 Acidform/N-9 users and abrasion occurred in nine of them. Vulvar irritation was seen in seven of these 10 volunteers. N-9 concentration in the gel (2.5% or 5.0%) was not related to the findings. No ulcer, exulceration, or de-epithelialization was observed. Acidform without N-9 was well tolerated by volunteers, but it was unable to protect the cervix, vagina, and vulva from the N-9 effects.
dc.description60
dc.description361-6
dc.languageeng
dc.relationContraception
dc.relationContraception
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAdult
dc.subjectCervix Uteri
dc.subjectColposcopy
dc.subjectDouble-blind Method
dc.subjectErythema
dc.subjectFemale
dc.subjectGels
dc.subjectHumans
dc.subjectHydrogen-ion Concentration
dc.subjectLeukocyte Count
dc.subjectMiddle Aged
dc.subjectNonoxynol
dc.subjectSexually Transmitted Diseases
dc.subjectSpermatocidal Agents
dc.subjectVagina
dc.subjectVaginal Creams, Foams, And Jellies
dc.subjectVulva
dc.subjectAmericas
dc.subjectBiology
dc.subjectBrazil
dc.subjectCervical Effects
dc.subjectCervix
dc.subjectClinical Research
dc.subjectContraception
dc.subjectContraceptive Agents
dc.subjectContraceptive Methods
dc.subjectDeveloping Countries
dc.subjectDiseases
dc.subjectFamily Planning
dc.subjectGenitalia
dc.subjectGenitalia, Female
dc.subjectInfections
dc.subjectLatin America
dc.subjectNonoxynol-9
dc.subjectPhysiology
dc.subjectReproductive Tract Infections
dc.subjectResearch Methodology
dc.subjectResearch Report
dc.subjectSexually Transmitted Diseases--prevention And Control
dc.subjectSouth America
dc.subjectSpermicidal Contraceptive Agents
dc.subjectUrogenital System
dc.subjectUterus
dc.subjectVaginal Jelly
dc.subjectVaginal Spermicides
dc.titleStudy Of The Vaginal Tolerance To Acidform, An Acid-buffering, Bioadhesive Gel.
dc.typeArtículos de revistas


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