Histologic And Functional Renal Alterations Caused By Bothrops Moojeni Snake Venom In Rats.

dc.creatorBoer-Lima, P A
dc.creatorGontijo, J A
dc.creatorda Cruz-Höfling, M A
dc.date1999-Nov
dc.date2015-11-27T12:19:45Z
dc.date2015-11-27T12:19:45Z
dc.date.accessioned2018-03-29T00:53:51Z
dc.date.available2018-03-29T00:53:51Z
dc.identifierThe American Journal Of Tropical Medicine And Hygiene. v. 61, n. 5, p. 698-706, 1999-Nov.
dc.identifier0002-9637
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/10586897
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/194453
dc.identifier10586897
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1294686
dc.descriptionAcute renal failure (ARF) is the main cause of death following snake bites by Bothrops species. In this study, we investigated the morphologic and functional renal disturbances caused by Bothrops moojeni venom in rats. Renal function was assessed based on creatinine and lithium clearances and on histologic examination of renal tissue 5 hr after the intravenous administration of 0.2 mg of venom/kg and 5 hr, 16 hr, and 48 hr after 0.4 mg of venom/ kg. A venom dose of 0.4 mg/kg produced renal tubule disturbances, including acute impairment of proximal and post-proximal tubule sodium handling associated with acute tubule necrosis. The glomerular filtration rate (GFR) decreased significantly and was accompanied by severe morphologic disturbances in the renal glomeruli. These functional and morphologic findings were observed in the absence of any change in mean arterial blood pressure. The decrease in GFR was not related to the presence of fibrin deposits in the glomerular capillary loops. These results suggest an early nephrotoxic action of B. moojeni venom involving significant morphologic and functional changes similar to those observed in snakebite-induced ARF in humans.
dc.description61
dc.description698-706
dc.languageeng
dc.relationThe American Journal Of Tropical Medicine And Hygiene
dc.relationAm. J. Trop. Med. Hyg.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAcute Kidney Injury
dc.subjectAnimals
dc.subjectBlood Pressure
dc.subjectBothrops
dc.subjectCreatinine
dc.subjectCrotalid Venoms
dc.subjectKidney Function Tests
dc.subjectKidney Glomerulus
dc.subjectKidney Tubules, Proximal
dc.subjectLithium
dc.subjectMale
dc.subjectPotassium
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectSnake Bites
dc.subjectSodium
dc.titleHistologic And Functional Renal Alterations Caused By Bothrops Moojeni Snake Venom In Rats.
dc.typeArtículos de revistas


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