Role Of Acetylcholine In Electrical Stimulation-induced Arrhythmia In Rat Isolated Atria.

dc.creatorGodoy, C M
dc.creatorBassani, R A
dc.creatorBassani, J W
dc.date1999-Oct
dc.date2015-11-27T12:19:42Z
dc.date2015-11-27T12:19:42Z
dc.date.accessioned2018-03-29T00:53:46Z
dc.date.available2018-03-29T00:53:46Z
dc.identifierJournal Of Cardiovascular Pharmacology. v. 34, n. 4, p. 475-9, 1999-Oct.
dc.identifier0160-2446
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/10511120
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/194429
dc.identifier10511120
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1294662
dc.descriptionIn this study, we used the spontaneously beating, isolated rat right atrium as an in vitro model to study arrhythmogenic effects of electrical stimulation. A tetrapolar platinum electrode was used for stimulation and recording of atrial electrical activity at 36.5 degrees C (spontaneous rate, 4.9+/-0.3 Hz). A flutter-like pattern of arrhythmia was reproducibly induced by application of stimulus trains (250 pulses, 66.7 Hz). Arrhythmia was characterized by regular and very short cycle length (40-70 ms), each episode lasting from 3 s to >5 min. In control conditions, application of one to five pulse trains was sufficient to induce arrhythmia. However, atropine (but not propranolol) completely blocked arrhythmia induction (10-15 consecutive trains were ineffective). The ability of electrical stimulation to evoke arrhythmia was restored after atropine washout. A milder stimulation protocol (30 pulses, 50 Hz), which was unable to evoke arrhythmia in control conditions, was fully effective in the presence of 1 microM acetylcholine (ACh). Furthermore, a similar flutter-like pattern could be induced in isolated left atria in the presence of ACh. Our results point out an arrhythmogenic effect of neurally released ACh in the isolated right atrium on atrial electrical stimulation.
dc.description34
dc.description475-9
dc.languageeng
dc.relationJournal Of Cardiovascular Pharmacology
dc.relationJ. Cardiovasc. Pharmacol.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAcetylcholine
dc.subjectAnimals
dc.subjectArrhythmias, Cardiac
dc.subjectAtrial Flutter
dc.subjectAtropine
dc.subjectElectric Stimulation
dc.subjectHeart Atria
dc.subjectIn Vitro Techniques
dc.subjectMale
dc.subjectPropranolol
dc.subjectRats
dc.subjectRats, Wistar
dc.titleRole Of Acetylcholine In Electrical Stimulation-induced Arrhythmia In Rat Isolated Atria.
dc.typeArtículos de revistas


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