Interferon Beta Modulates Experimental Autoimmune Encephalomyelitis By Altering The Pattern Of Cytokine Secretion.

dc.creatorYasuda, C L
dc.creatorAl-Sabbagh, A
dc.creatorOliveira, E C
dc.creatorDiaz-Bardales, B M
dc.creatorGarcia, A A
dc.creatorSantos, L M
dc.date
dc.date2015-11-27T12:19:41Z
dc.date2015-11-27T12:19:41Z
dc.date.accessioned2018-03-29T00:53:43Z
dc.date.available2018-03-29T00:53:43Z
dc.identifierImmunological Investigations. v. 28, n. 2-3, p. 115-26
dc.identifier0882-0139
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/10484677
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/194420
dc.identifier10484677
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1294653
dc.descriptionThe mechanism of action underlying the beneficial effect of IFNbeta in Multiple Sclerosis is poorly understood. Experimental Autoimmune Encephalomyelitis (EAE) is the experimental model for Multiple Sclerosis; therefore, we investigated the effects of recombinant mouse IFNbeta on the severity of EAE induced in SJL mice and on cytokine production by Th1 and Th2 lymphocytes. The results indicated that rmIFN beta reduced the disease activity with an I.P. dosage of 10,000 U/day every other day, and successfully treated EAE mice revealed reduced amounts of IFN gamma; no changes in the levels of IL4 were observed, although thera was a significant increase in IL10 and TGFbeta production. Beneficial effects on EAE are associated with inhibition of inflammatory cytokines and stimulation of anti-inflammatory cytokines.
dc.description28
dc.description115-26
dc.languageeng
dc.relationImmunological Investigations
dc.relationImmunol. Invest.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectCell Division
dc.subjectCytokines
dc.subjectEncephalomyelitis, Autoimmune, Experimental
dc.subjectFemale
dc.subjectInterferon-beta
dc.subjectInterleukin-10
dc.subjectMice
dc.subjectRecombinant Proteins
dc.subjectT-lymphocytes
dc.subjectTransforming Growth Factor Beta
dc.titleInterferon Beta Modulates Experimental Autoimmune Encephalomyelitis By Altering The Pattern Of Cytokine Secretion.
dc.typeArtículos de revistas


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