Activation Of Renal Pelvic Chemoreceptors In Rats: Role Of Calcitonin Gene-related Peptide Receptors.

dc.creatorGontijo, J A
dc.creatorKopp, U C
dc.date1999-Jun
dc.date2015-11-27T12:19:37Z
dc.date2015-11-27T12:19:37Z
dc.date.accessioned2018-03-29T00:53:33Z
dc.date.available2018-03-29T00:53:33Z
dc.identifierActa Physiologica Scandinavica. v. 166, n. 2, p. 159-65, 1999-Jun.
dc.identifier0001-6772
dc.identifier10.1046/j.1365-201x.1999.00540.x
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/10383496
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/194374
dc.identifier10383496
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1294607
dc.descriptionSubstance P and calcitonin gene-related peptide (CGRP) increase afferent renal nerve activity (ARNA). A substance P receptor antagonist but not a CGRP receptor antagonist, h-CGRP (8-37), blocks the ARNA response to renal mechanoreceptor (MR) stimulation. We have examined whether calcitonin gene-related peptide activates renal pelvic sensory receptors and whether such activation contributes to renal chemoreceptor stimulation. The calcitonin gene-related peptide receptor antagonist, h-CGRP (8-37) [0.01-10 micromol L-1] dose-dependently decreased (29 +/- 4-86 +/- 13%, P < 0.01) the ipsilateral afferent renal nerve activity in response to the renal pelvic administration of calcitonin gene-related peptide (0.26 micromol L-1). Renal pelvic perfusion with 900 mM NaCl also increased ipsilateral ARNA (23 +/- 3% increase, P < 0.02) and contralateral urinary sodium excretion (13 +/- 4% increase, P < 0. 05). However, these responses to hypertonic NaCl were unaltered by h-CGRP (8-37). Renal pelvic perfusion with 1 or 10 microM h-CGRP (8-37) also failed to alter the ARNA responses to KCl (31.25, 62.5 and 125 mM). These results indicate that there are sensory receptors in the renal pelvic area that are responsive to calcitonin gene-related peptide. The activation of these receptors elicits a contralateral natriuretic response. In contrast, the activation of renal calcitonin gene-related peptide receptors does not contribute to renal chemoreceptor activation.
dc.description166
dc.description159-65
dc.languageeng
dc.relationActa Physiologica Scandinavica
dc.relationActa Physiol. Scand.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectCalcitonin Gene-related Peptide
dc.subjectChemoreceptor Cells
dc.subjectKidney Pelvis
dc.subjectMale
dc.subjectNeurons, Afferent
dc.subjectPeptide Fragments
dc.subjectPotassium Chloride
dc.subjectRats
dc.subjectRats, Sprague-dawley
dc.subjectReceptors, Calcitonin Gene-related Peptide
dc.subjectSodium Chloride
dc.titleActivation Of Renal Pelvic Chemoreceptors In Rats: Role Of Calcitonin Gene-related Peptide Receptors.
dc.typeArtículos de revistas


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