Reduced Responsiveness To Noradrenaline In Isolated Rat Atria Exposed To Hyperosmotic Solutions.

dc.creatorBassani, R A
dc.creatorBassani, J W
dc.date1991
dc.date2015-11-27T12:19:36Z
dc.date2015-11-27T12:19:36Z
dc.date.accessioned2018-03-29T00:53:31Z
dc.date.available2018-03-29T00:53:31Z
dc.identifierGeneral Pharmacology. v. 22, n. 1, p. 151-7, 1991.
dc.identifier0306-3623
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/2050282
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/194367
dc.identifier2050282
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1294600
dc.description1. The effects of hyperosmotic NaCl and sucrose solutions on the responsiveness to noradrenaline (NA) were studied in isolated rat right and left atria. 2. Sucrose caused subsensitivity to NA and isoprenaline in right atria, which was abolished by atropine. 3. NaCl caused subsensitivity only to NA in both atria, which was reversed by imipramine. 4. Both solutions decreased the maximum tension of left atria after maximal NA and Ca2+ concentrations. 5. The results suggest that hyperosmolality reduces the atrial responsiveness to NA by directly depressing contractility and increasing acetylcholine release. However, if the solute is NaCl, the main mechanism seems to be an increase of the catecholamine neuronal uptake.
dc.description22
dc.description151-7
dc.languageeng
dc.relationGeneral Pharmacology
dc.relationGen. Pharmacol.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectAtropine
dc.subjectCalcium
dc.subjectCalcium Chloride
dc.subjectHeart
dc.subjectHeart Rate
dc.subjectHypertonic Solutions
dc.subjectImipramine
dc.subjectIn Vitro Techniques
dc.subjectIsoproterenol
dc.subjectMale
dc.subjectMyocardial Contraction
dc.subjectNorepinephrine
dc.subjectOsmolar Concentration
dc.subjectRats
dc.subjectRats, Inbred Strains
dc.subjectSodium Chloride
dc.subjectSucrose
dc.titleReduced Responsiveness To Noradrenaline In Isolated Rat Atria Exposed To Hyperosmotic Solutions.
dc.typeArtículos de revistas


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