Spontaneous Erythroid Colony Formation In Brazilian Patients With Sickle Cell Disease.

dc.creatorPerlingeiro, R C
dc.creatorCosta, F F
dc.creatorSaad, S T
dc.creatorArruda, V R
dc.creatorQueiroz, M L
dc.date1999-May
dc.date2015-11-27T12:19:35Z
dc.date2015-11-27T12:19:35Z
dc.date.accessioned2018-03-29T00:53:29Z
dc.date.available2018-03-29T00:53:29Z
dc.identifierAmerican Journal Of Hematology. v. 61, n. 1, p. 40-5, 1999-May.
dc.identifier0361-8609
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/10331510
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/194359
dc.identifier10331510
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1294592
dc.descriptionThe ability of circulating progenitor cells to develop erythroid colonies was studied in vitro in the presence or absence of growth factors (5637-CM and erythropoietin) in 63 patients with sickle cell disease (SCD) (36 homozygotes for hemoglobin [Hb] S, 13 double heterozygotes for Hb S and beta thalassemia, and 14 SC patients) in Southeast Brazil. In the presence of growth factors, SCD patients (all genotypes) presented significantly higher numbers of circulating burst-forming unit-erythroid (BFU-E/5 x 10(5) MNC), when compared with control subjects. However, when the progenitor cells were cultured in the absence of added stimulus, high numbers of BFU-E were observed only in the genotypes SS and S/beta thalassemia. SC patients presented a similar response to the control subjects. Moreover, there was an inverse correlation between spontaneous (without stimulus) BFU-E and Hb levels in SCD patients. These results suggest that the formation of spontaneous BFU-E observed in SCD may be due to an expanded erythropoiesis secondary to hemolysis.
dc.description61
dc.description40-5
dc.languageeng
dc.relationAmerican Journal Of Hematology
dc.relationAm. J. Hematol.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAdult
dc.subjectAnemia, Sickle Cell
dc.subjectBrazil
dc.subjectCell Differentiation
dc.subjectCell Division
dc.subjectColony-forming Units Assay
dc.subjectErythroid Precursor Cells
dc.subjectErythropoietin
dc.subjectGenotype
dc.subjectHemoglobin Sc Disease
dc.subjectHumans
dc.subjectRecombinant Proteins
dc.subjectSickle Cell Trait
dc.subjectBeta-thalassemia
dc.titleSpontaneous Erythroid Colony Formation In Brazilian Patients With Sickle Cell Disease.
dc.typeArtículos de revistas


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