The Neuromuscular Action Of Ancylometes Sp. Spider Venom In The Rat Phrenic Nerve-diaphragm Preparation.

dc.creatorGrégio, A M
dc.creatorHeleno, M G
dc.creatorVon Eicksted, V R
dc.creatorFontana, M D
dc.date1999-Mar
dc.date2015-11-27T12:19:33Z
dc.date2015-11-27T12:19:33Z
dc.date.accessioned2018-03-29T00:53:25Z
dc.date.available2018-03-29T00:53:25Z
dc.identifierToxicon : Official Journal Of The International Society On Toxinology. v. 37, n. 3, p. 545-50, 1999-Mar.
dc.identifier0041-0101
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/10080357
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/194339
dc.identifier10080357
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1294572
dc.descriptionThe effects of Ancylometes sp. venom on muscle contraction and bioelectrical potentials were investigated in the rat phrenic nerve diaphragm muscle preparation. The venom (50 microg/ml) depolarized the diaphragm muscle fiber membranes. This effect was abolished by tetrodotoxin and by reduction of the sodium concentration of the Tyrode solution. The increase in the frequency of miniature end plate potentials induced by the venom was also suppressed by tetrodotoxin (3 microM). These results indicate that the venom may activate voltage-dependent sodium channels in cell membranes. All of the effects of Ancylometes sp. venom on this nerve muscle preparation (i.e. increase in twitch tension, spontaneous small phasic contractions and increase in the frequency of miniature end-plate potentials) may be explained in terms of its action on sodium channels.
dc.description37
dc.description545-50
dc.languageeng
dc.relationToxicon : Official Journal Of The International Society On Toxinology
dc.relationToxicon
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectDiaphragm
dc.subjectDrug Interactions
dc.subjectMale
dc.subjectMembrane Potentials
dc.subjectNerve Endings
dc.subjectPhrenic Nerve
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectSodium
dc.subjectSpider Venoms
dc.subjectTetrodotoxin
dc.titleThe Neuromuscular Action Of Ancylometes Sp. Spider Venom In The Rat Phrenic Nerve-diaphragm Preparation.
dc.typeArtículos de revistas


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