Haematopoietic Response And Bcl-2 Expression In Patients With Acute Myeloid Leukaemia.

dc.creatorBincoletto, C
dc.creatorSaad, S T
dc.creatorda Silva, E S
dc.creatorQueiroz, M L
dc.date1999-Jan
dc.date2015-11-27T12:19:32Z
dc.date2015-11-27T12:19:32Z
dc.date.accessioned2018-03-29T00:53:23Z
dc.date.available2018-03-29T00:53:23Z
dc.identifierEuropean Journal Of Haematology. v. 62, n. 1, p. 38-42, 1999-Jan.
dc.identifier0902-4441
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/9918310
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/194329
dc.identifier9918310
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1294562
dc.descriptionBcl-2 expression, the number of apoptotic cells and the growth and differentiation of early bone marrow progenitor cells were studied in patients with confirmed diagnosis of acute myeloid leukaemia (AML). Bone marrow cells from normal individuals were used as controls. We observed an increased percentage of bcl-2-mononuclear bone marrow cells expression in AML patients in relation to controls (p =0.002). Accordingly, the number of apoptotic cells was reduced (p = 0.001) and there was a negative correlation between bcl-2 expression and the number of apoptotic cells (r=-0.664, p<0.001). In addition, bcl-2 expression was significantly increased in the chemotherapy resistant group in relation to the responsive group (p = 0.03). Lower rate of survival was observed in the group of AML patients with autonomous proliferation (p=0.01). These results suggest that a high bcl-2 expression and the presence of autonomous proliferation are related to a poor prognosis in AML.
dc.description62
dc.description38-42
dc.languageeng
dc.relationEuropean Journal Of Haematology
dc.relationEur. J. Haematol.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAcute Disease
dc.subjectApoptosis
dc.subjectBone Marrow Cells
dc.subjectCell Count
dc.subjectCell Division
dc.subjectCell Survival
dc.subjectColony-forming Units Assay
dc.subjectHumans
dc.subjectLeukemia, Myeloid
dc.subjectLeukocytes, Mononuclear
dc.subjectProto-oncogene Proteins C-bcl-2
dc.titleHaematopoietic Response And Bcl-2 Expression In Patients With Acute Myeloid Leukaemia.
dc.typeArtículos de revistas


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