Mitochondrial Damage Induced By Conditions Of Oxidative Stress.

dc.creatorKowaltowski, A J
dc.creatorVercesi, A E
dc.date1999-Feb
dc.date2015-11-27T12:19:32Z
dc.date2015-11-27T12:19:32Z
dc.date.accessioned2018-03-29T00:53:23Z
dc.date.available2018-03-29T00:53:23Z
dc.identifierFree Radical Biology & Medicine. v. 26, n. 3-4, p. 463-71, 1999-Feb.
dc.identifier0891-5849
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/9895239
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/194328
dc.identifier9895239
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1294561
dc.descriptionUp to 2% of the oxygen consumed by the mitochondrial respiratory chain undergoes one electron reduction, typically by the semiquinone form of coenzyme Q, to generate the superoxide radical, and subsequently other reactive oxygen species such as hydrogen peroxide and the hydroxyl radical. Under conditions in which mitochondrial generation of reactive oxygen species is increased (such as in the presence of Ca2+ ions or when the mitochondrial antioxidant defense mechanisms are compromised), these reactive oxygen species may lead to irreversible damage of mitochondrial DNA, membrane lipids and proteins, resulting in mitochondrial dysfunction and ultimately cell death. The nature of this damage and the cellular conditions in which it occurs are discussed in this review article.
dc.description26
dc.description463-71
dc.languageeng
dc.relationFree Radical Biology & Medicine
dc.relationFree Radic. Biol. Med.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectApoptosis
dc.subjectDna Damage
dc.subjectDna, Mitochondrial
dc.subjectElectron Transport
dc.subjectHumans
dc.subjectLipid Peroxidation
dc.subjectMembrane Proteins
dc.subjectMitochondria
dc.subjectNecrosis
dc.subjectOxidation-reduction
dc.subjectOxidative Stress
dc.subjectPermeability
dc.subjectReactive Oxygen Species
dc.titleMitochondrial Damage Induced By Conditions Of Oxidative Stress.
dc.typeArtículos de revistas


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