Chronic Prenatal Stress Affects Development And Behavioral Depression In Rats.

dc.creatorSecoli, S R
dc.creatorTeixeira, N A
dc.date1998-Dec
dc.date2015-11-27T12:19:26Z
dc.date2015-11-27T12:19:26Z
dc.date.accessioned2018-03-29T00:53:10Z
dc.date.available2018-03-29T00:53:10Z
dc.identifierStress (amsterdam, Netherlands). v. 2, n. 4, p. 273-80, 1998-Dec.
dc.identifier1025-3890
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/9876258
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/194275
dc.identifier9876258
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1294508
dc.descriptionWe have used the approach of Willner et al (1987), which consists of transitory and variable changes in the rats living conditions, to investigate the influence of chronic prenatal stress on pup development and their susceptibility to behavioral depression at adult age, as assessed by the learned helplessness model. Pregnant female Wistar rats were divided into either stressed (S; N = 35) or non-stressed (NS; N = 35) groups during the last two weeks of pregnancy. The male and female pups of both groups were either handled to test for physical development up to weaning (H; N = 25 litters) or left undisturbed (NH; N = 10 litters) until adult age, at which time the males from all four experimental groups were divided into two subgroups (N = 10 each) and were submitted to the learned helplessness model of depression. Prenatal stress reduced the number of male pups per litter, decreased the anogenital distance, and produced earlier earflap and eye opening dates, as well as a faster righting. Behavioral depression was induced in all cases, except in the NS-H animals. The prenatally stressed, non-handled pups showed greater escape latency than the NS subgroups. We conclude that the stress schedule used in this study was stressful to dams and sufficient to affect the pups development and to increase the intensity of induced behavioral depression at adult age.
dc.description2
dc.description273-80
dc.languageeng
dc.relationStress (amsterdam, Netherlands)
dc.relationStress
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAge Factors
dc.subjectAnal Canal
dc.subjectAnalysis Of Variance
dc.subjectAnimals
dc.subjectAnimals, Newborn
dc.subjectBehavior, Animal
dc.subjectBody Weight
dc.subjectChronic Disease
dc.subjectDepression
dc.subjectDisease Models, Animal
dc.subjectFemale
dc.subjectGenitalia
dc.subjectHelplessness, Learned
dc.subjectMale
dc.subjectMaternal Behavior
dc.subjectPregnancy
dc.subjectPrenatal Exposure Delayed Effects
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectReflex
dc.subjectSex Factors
dc.subjectStress, Physiological
dc.titleChronic Prenatal Stress Affects Development And Behavioral Depression In Rats.
dc.typeArtículos de revistas


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