Accelerated Recovery Of Glycerol-induced Acute Renal Failure In Rats With Previous Partial Hepatectomy.

dc.creatorHomsi, E
dc.creatorPires de Oliveira Dias, E
dc.creatorFigueiredo, J F
dc.creatorGontijo, J A
dc.date
dc.date2015-11-27T12:19:24Z
dc.date2015-11-27T12:19:24Z
dc.date.accessioned2018-03-29T00:53:07Z
dc.date.available2018-03-29T00:53:07Z
dc.identifierExperimental Nephrology. v. 6, n. 6, p. 551-6
dc.identifier1018-7782
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/9807027
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/194259
dc.identifier9807027
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1294492
dc.descriptionSeveral studies have reported a favorable effect following the administration of growth factors during the course of acute renal failure. To evaluate the effect of an increased endogenous production of growth factors, rats underwent 70% hepatectomy before glycerol-induced acute renal failure. The renal function was then monitored 12 and 48 h after glycerol injection in conscious rats. Twelve hours after the induction of acute renal failure, a reduction in creatinine clearance and sodium reabsorption was seen in both prehepatectomized and sham-hepatectomized rats. At 48 h, there was total recovery of glomerular filtration and tubular function in the prehepatectomized rats, whereas the sham-hepatectomized rats still had reduced glomerular filtration and sodium reabsorption. In rats treated with dexamethasone before hepatectomy and studied 48 h after the induction of acute renal failure, the protective action on renal function seen in prehepatectomized rats was totally blocked. A semiquantitative histological analysis done 48 h after the induction of acute renal failure demonstrated a fourfold increase in the number of necrotic tubules in both sham-hepatectomized and dexamethasone-treated rats as compared with hepatectomized rats. It is concluded that partial hepatectomy, a maneuver used to increase the endogenous synthesis of growth factors, accelerates recovery of renal function following glycerol-induced acute renal failure.
dc.description6
dc.description551-6
dc.languageeng
dc.relationExperimental Nephrology
dc.relationExp. Nephrol.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAbsorption
dc.subjectAcute Kidney Injury
dc.subjectAnimals
dc.subjectCreatinine
dc.subjectDexamethasone
dc.subjectGlomerular Filtration Rate
dc.subjectGlucocorticoids
dc.subjectGlycerol
dc.subjectHepatectomy
dc.subjectKidney
dc.subjectKidney Tubules
dc.subjectMale
dc.subjectPostoperative Period
dc.subjectPreoperative Care
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectSodium
dc.subjectTime Factors
dc.titleAccelerated Recovery Of Glycerol-induced Acute Renal Failure In Rats With Previous Partial Hepatectomy.
dc.typeArtículos de revistas


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