The Effect Of Bacterial Lipopolysaccharide On Gastric Emptying In Rats Suffering From Moderate Renal Insufficiency.

dc.creatorRigatto, S Z
dc.creatorCollares, E F
dc.date1998-Apr
dc.date2015-11-27T12:19:18Z
dc.date2015-11-27T12:19:18Z
dc.date.accessioned2018-03-29T00:52:55Z
dc.date.available2018-03-29T00:52:55Z
dc.identifierBrazilian Journal Of Medical And Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas / Sociedade Brasileira De Biofísica ... [et Al.]. v. 31, n. 4, p. 515-8, 1998-Apr.
dc.identifier0100-879X
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/9698802
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/194210
dc.identifier9698802
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1294443
dc.descriptionThe objective of the present study was to evaluate the response of rats suffering from moderate renal insufficiency to bacterial lipopolysaccharide (LPS, or endotoxin). The study involved 48 eight-week-old male SPF Wistar rats (175-220 g) divided into two groups of 24 animals each. One group underwent 5/6 nephrectomy while the other was sham-operated. Two weeks after surgery, the animals were further divided into two subgroups of 12 animals each and were fasted for 20 h but with access to water ad libitum. One nephrectomized and one sham-treated subgroup received E. coli LPS (25 micrograms/kg, i.v.) while the other received a sterile, pyrogen-free saline solution. Gastric retention (GR) was determined 10 min after the orogastric infusion of a standard saline test meal labeled with phenol red (6 mg/dl). The gastric emptying of the saline test meal was studied after 2 h. Renal function was evaluated by measuring the plasma levels of urea and creatinine. The levels of urea and creatinine in 5/6 nephrectomized animals were two-fold higher than those observed in the sham-operated rats. Although renal insufficiency did not change gastric emptying (median %GR = 26.6 for the nephrectomized subgroup and 29.3 for the sham subgroup), LPS significantly retarded the gastric emptying of the sham and nephretomized groups (median %GR = 42.0 and 61.0, respectively), and was significantly greater (p < 0.01) in the nephrectomized rats. We conclude that gastric emptying in animals suffering from moderate renal insufficiency is more sensitive to the action of LPS than in sham animals.
dc.description31
dc.description515-8
dc.languageeng
dc.relationBrazilian Journal Of Medical And Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas / Sociedade Brasileira De Biofísica ... [et Al.]
dc.relationBraz. J. Med. Biol. Res.
dc.rightsaberto
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectCreatinine
dc.subjectEscherichia Coli
dc.subjectGastric Emptying
dc.subjectLipopolysaccharides
dc.subjectMale
dc.subjectNephrectomy
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectRenal Insufficiency
dc.subjectUrea
dc.titleThe Effect Of Bacterial Lipopolysaccharide On Gastric Emptying In Rats Suffering From Moderate Renal Insufficiency.
dc.typeArtículos de revistas


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