Effect Of Propranolol And Nifedipine On In Vitro Fluid Absorption By The Isolated Perfused Proximal Convoluted Tubule Of The Rabbit.

dc.creatorFigueiredo, J F
dc.creatorFalkenstein, D
dc.date1991
dc.date2015-11-27T12:19:17Z
dc.date2015-11-27T12:19:17Z
dc.date.accessioned2018-03-29T00:52:53Z
dc.date.available2018-03-29T00:52:53Z
dc.identifierBrazilian Journal Of Medical And Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas / Sociedade Brasileira De Biofísica ... [et Al.]. v. 24, n. 12, p. 1265-8, 1991.
dc.identifier0100-879X
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/1843877
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/194202
dc.identifier1843877
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1294435
dc.descriptionThe inhibition of fluid absorption (Jv) by the antiarrhythmic and antihypertensive drugs propranolol and nifedipine, which increase cytosolic Ca2+ concentration, was studied using the isolated rabbit proximal convoluted tubule perfused in vitro. Proximal convoluted tubules were perfused and bathed with a modified Krebs-Henseleit solution containing bovine serum albumin. Jv was measured after a 30-min control period, after 40 min with either 0.1 mM propranolol or 1.0 mM nifedipine on the peritubular side and after a 40-min recovery period. Both drugs inhibited Jv (58% propranolol, and 21% nifedipine). The 40-min recovery period was sufficient to reverse the effect of nifedipine, but propranolol-treated tubules (N = 6) only reached 78% of the control Jv value. These results demonstrate that antiarrhythmic and antihypertensive drugs are powerful inhibitors of net fluid absorption by exerting a direct effect on proximal or distal tubule cells, thus acting like local diuretics.
dc.description24
dc.description1265-8
dc.languageeng
dc.relationBrazilian Journal Of Medical And Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas / Sociedade Brasileira De Biofísica ... [et Al.]
dc.relationBraz. J. Med. Biol. Res.
dc.rightsaberto
dc.rights
dc.sourcePubMed
dc.subjectAbsorption
dc.subjectAnimals
dc.subjectIn Vitro Techniques
dc.subjectKidney Tubules, Proximal
dc.subjectNifedipine
dc.subjectPropranolol
dc.subjectRabbits
dc.subjectTime Factors
dc.titleEffect Of Propranolol And Nifedipine On In Vitro Fluid Absorption By The Isolated Perfused Proximal Convoluted Tubule Of The Rabbit.
dc.typeArtículos de revistas


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